Associations of sympathetic activation with exposure to volatile organic compounds: A cross-sectional study

被引:0
作者
Stopforth, Cameron K. [1 ,2 ]
Sears, Clara [1 ,3 ]
Gao, Hong [1 ,3 ]
Riggs, Daniel W. [1 ,3 ]
Srivastava, Shweta [1 ,3 ]
Krivokhizhina, Tatiana [1 ,3 ]
Hart, Joy L. [1 ,4 ]
Walker, Kandi L. [1 ,4 ]
Srivastava, Sanjay [1 ,3 ]
Bhatnagar, Aruni [1 ,3 ]
Keith, Rachel J. [1 ,3 ]
机构
[1] Univ Louisville, Sch Med, Christina Lee Brown Envirome Inst, 302 Muhammad Ali Blvd, Louisville, KY 40202 USA
[2] Univ Louisville, Sch Med, Dept Physiol, 500 S Preston St, Louisville, KY 40202 USA
[3] Univ Louisville, Sch Med, Dept Med, 550 S Jackson St, Louisville, KY 40202 USA
[4] Univ Louisville, Coll Arts & Sci, Dept Commun, Strickler Hall, Louisville, KY 40292 USA
关键词
Volatile organic compounds; Air pollution; Monoamines; Catecholamines; Sympathetic nervous system; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; OCCUPATIONAL NOISE; AIR-POLLUTION; CREATININE; DISTRIBUTIONS; TRANSPORTERS; METABOLITES; SEROTONIN; CHEMICALS;
D O I
10.1016/j.envres.2025.122451
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Volatile organic compounds (VOCs) are ubiquitous gaseous chemicals emitted from multiple sources and present in both indoor and outdoor air. VOC exposures have been linked to detrimental cardiometabolic effects; nevertheless, the underlying mechanisms remain unclear. In this study, we evaluated the relationship between VOC exposure and sympathetic activation. Methods: Participants (n=696, age 25-70 years) were recruited between 2018 and 2021 in Louisville, KY. Clean catch, spot urine samples were obtained. Urinary metabolites of VOCs and monoamines were quantified using UPLC-MS/MS. The associations of creatinine-adjusted, log-transformed urinary constituents were examined using adjusted multivariable linear regression models for individual metabolites and quantile-based g-computation for overall mixture models. Final models were adjusted for demographics, stress, smoking status, medication use, and urine collection time. Results: Higher urinary levels of several VOC metabolites were associated with higher urinary levels of monoamines and their metabolites. A quartile increase in the overall VOC metabolite mixture was associated with 27% [18%, 37%] (serotonin) to 54% [36%, 73%] (epinephrine) higher urinary parent monoamine concentrations. For phase I monoamine metabolites, concentrations were 25% [16%, 35%] (vanillylmandelic acid) to 37% [29%, 46%] (3-methoxytyramine) higher per quartile increase in VOC metabolite mixture. Conclusions: Our results suggest that exposure to VOCs is associated with elevated sympathetic activation. Individual and mixture analyses identified robust associations with metabolites of N,N-dimethylformamide, 1,3butadiene, ethylbenzene/styrene, propylene oxide, and crotonaldehyde. Elevated sympathetic tone may be a significant contributor to the negative cardiometabolic outcomes associated with VOC exposure.
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页数:10
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