Both numerical simulation and experiment are used to research the effect of single pulse laser energy deposition on supersonic wave drag. First, under the supersonic flow of Ma 5, the effect of energy deposition on wave drag is investigated with numerical simulation. The reason of drag reduction is analyzed by the law of the pressure, temperature contours and the parameter change of stagnation point. The results show that the bow shock over blunt body is deformed due to the energy deposition. The shock stand-off distance is increased, the surface pressure of blunt body is decreased and the wave drag is reduced by 13%. The experimental system is set up, and the interaction of shock and bow shock over the blunt body is screened by the schlieren system. The results of experiment and simulation are almost consistent.