Streptozotocin-Induced Diabetic Models in Mice and Rats

被引：987
作者：
Furman, Brian L. [1 ]
机构：
[1] Strathclyde Inst Pharm & Biomed Sci, Glasgow, Lanark, Scotland
来源：
CURRENT PROTOCOLS | 2021年 / 1卷 / 04期
关键词：
high-fat; hyperglycemia; insulin deficiency; insulin resistance; insulitis; mouse or rat; nicotinamide; streptozotocin; type 1 diabetes mellitus; type 2 diabetes mellitus;
D O I：
10.1002/cpz1.78
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Streptozotocin (STZ) is an antibiotic that causes pancreatic islet beta-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ-induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition. (c) 2021 The Authors.
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页数：21
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