Advances in the mechanisms of drug resistance of Mycobacterium tuberculosis

被引：0

作者：

Sikandar, Muhammad ^{[1
]}

Xing, Li ^{[1
]}

机构：

[1] Shanxi Univ, Inst Biomed Sci, 92 Wucheng Rd, Taiyuan 030006, Shanxi, Peoples R China

来源：

MICROBIAL PATHOGENESIS | 2025年 / 206卷

关键词：

Mycobacterium tuberculosis; Drug resistance; Antimicrobial; Replication; Mutation; PARA-AMINOSALICYLIC ACID; ETHAMBUTOL RESISTANCE; PYRAZINAMIDE RESISTANCE; CAPREOMYCIN RESISTANCE; HIGH-LEVEL; IN-VITRO; ANTITUBERCULOUS ACTIVITY; PHENOTYPIC RESISTANCE; CROSS-RESISTANCE; UBIA MUTATIONS;

D O I：

10.1016/j.micpath.2025.107861

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), has developed different mechanism of action against antimicrobial drug therapies, posing a significant threat to effective treatment against Mtb. This review article provides an overview of the recent advancements in the mechanism of drug resistance in Mtb and highlights how drugs target specific cellular processes. Additionally, we also discuss the intrinsic resistance mechanisms employed by Mtb and how alterations in drug target sites contribute to treatment failure.

引用

页数：18

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