Advances in hydrogel-based materials for breast cancer bone metastasis: from targeted drug delivery to bone microenvironment remodeling

被引：0
作者：
Chen, Jiayi [1 ]
Ma, Jun [1 ]
Xu, Zhuoming [1 ]
Luo, Huanhuan [1 ]
Qian, Chenhong [1 ]
机构：
[1] Jiaxing Univ, Affiliated Hosp 2, Dept Orthopaed, Jiaxing Key Lab Basic Res & Clin Translat Orthoped, Jiaxing, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2025年 / 16卷
基金：
中国国家自然科学基金;
关键词：
breast cancer; bone metastasis; drug delivery; multifunctional platform; bone regeneration; PRACTICE GUIDELINES; TUMOR; THERAPY; CHEMOTHERAPY; RADIOTHERAPY; PROGNOSIS; SURVIVAL;
D O I：
10.3389/fphar.2025.1627883
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Breast cancer has become the most common malignant tumor in women around the world, and bones are the most common part of all metastatic breast cancers. Breast cancer bone metastasis (BCBM) is the main cause of death in patients with advanced breast cancer. It is still mainly clinically palliative treatment, with problems such as systemic toxicity, low target specificity, and insufficient bone repair. Therefore, there is an urgent need to develop new therapeutic strategies to overcome these challenges. This review summarizes recent advances and innovative applications of smart hydrogel-based delivery systems for breast cancer bone metastasis, highlighting their significant potential in gene delivery and immune microenvironment remodeling. Current limitations and future research directions are also discussed.
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页数：24
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