Lutetium-Based Nanoprobes for Radiosensitization with Immune Microenvironment Remodeling and NIR-II Fluorescence Imaging-Guided Surgery in Colorectal Cancer

被引：0

作者：

Dang, Yongying ^{[1
]}

Liu, Xianzhi ^{[1
]}

Zheng, Zifan ^{[1
]}

Wang, Ao ^{[2
]}

Huang, Ying ^{[3
]}

Luo, Zhong ^{[1
]}

Tian, Haina ^{[4
,5
]}

Li, Siyaqi ^{[2
]}

Luo, Qiang ^{[2
]}

Wang, Peiyuan ^{[2
]}

He, Weiling ^{[1
]}

机构：

[1] Xiamen Univ, Xiangan Hosp, Sch Med, Dept Gastrointestinal Surg, Xiamen 361100, Peoples R China

[2] Chinese Acad Sci, Key Lab Design & Assembly Funct Nanostruct, Fujian Inst Res Struct Matter, Fuzhou 350002, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Etiol & Carcinogenesis, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100021, Peoples R China

[4] Fuyang Normal Univ, Sch Chem & Mat Engn, Fuyang 236037, Anhui, Peoples R China

[5] Fuyang Normal Univ, Engn Res Ctr Biomass Convers & Pollut Prevent Cont, Dept Educ, Fuyang 236037, Peoples R China

来源：

ADVANCED SCIENCE | 2025年

基金：

中国国家自然科学基金;

关键词：

colorectal cancer; immune microenvironment remodeling; NIR-II fluorescence imaging; precise discrimination of surgical margins; radiotherapy sensitization; IMMUNOTHERAPY; RADIOTHERAPY;

D O I：

10.1002/advs.202510136

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Colorectal cancer (CRC) is among the top five leading cancers worldwide. Preoperative concurrent chemoradiotherapy is recommended for locally advanced CRC. Radiotherapy (RT), a traditional cancer treatment, not only controls local tumor growth but also potentially induces immunogenic cell death, initiating systemic immune responses. Given the poor radiosensitivity of CRC, improving RT sensitization is a critical unmet need. Despite advances in intraoperative imaging, achieving complete resection of colorectal tumors with clear margins in real time remains a significant clinical challenge. This study introduces RVLu@ICG, a novel multifunctional fluorescent nanoprobe emitting in the second near-infrared (NIR-II) range. It's demonstrated that RVLu@ICG has tumor-specific targeting due to modification with cyclic arginine-glycine-aspartic acid (c(RGDfK)) pentapeptide and induces augmented reactive oxygen species (ROS) production under ionizing radiation exposure. This synergistic mechanism not only potentiates radiosensitization efficacy but also facilitates radiation-induced remodeling of the tumor immune microenvironment. Additionally, NIR-II fluorescence image guidance facilitates precise surgical navigation in microtumor models, intramuscular tumor invasion models, and peritoneal metastasis models. Notably, the nanoprobe demonstrates excellent biocompatibility both in vitro and in vivo. Thus, RVLu@ICG establishes a robust precision therapy platform for the treatment of CRC.

引用

页数：18