Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder

被引：0

作者：

Pardo, Jessica ^{[1
,2
]}

Roura, Ignacio ^{[1
,2
]}

Montal, Victor ^{[3
,4
]}

Martin-Barcelo, Cristina ^{[1
,2
]}

Oltra, Javier ^{[1
,2
,5
,6
]}

Campabadal, Anna ^{[1
,2
,7
]}

Bargallo, Nuria ^{[2
,8
,9
]}

Serradell, Monica ^{[10
]}

Maya, Gerard ^{[10
]}

Montini, Angelica ^{[10
]}

Gaig, Carles ^{[2
,10
]}

Pont-Sunyer, Claustre ^{[11
]}

Fortea, Juan ^{[3
,12
,13
]}

Iranzo, Alex ^{[2
,10
,12
]}

Junque, Carme ^{[1
,2
,12
]}

Segura, Barbara ^{[1
,2
,12
]}

机构：

[1] Univ Barcelona, Inst Neurosci, Dept Med, Med Psychol Unit, Barcelona, Spain

[2] Inst Invest Biomed August Pi & Sunyer FRCB IDIBAPS, Fundacio Recerca Clin Barcelona, Barcelona, Spain

[3] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain

[4] Barcelona Supercomp Ctr, Dept Life Sci, Barcelona, Spain

[5] Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

[6] Stockholm Univ, Stockholm, Sweden

[7] Consorci Corp Sanit Parc Tauli Sabadell, Neurol Serv, Barcelona, Spain

[8] Hosp Clin Univ Barcelona, Imaging Diagnost Ctr CDI, Barcelona, Spain

[9] Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

[10] Univ Barcelona, Hosp Clin Univ Barcelona, Sleep Disorders Ctr, Neurol Serv, Barcelona, Spain

[11] Fundacio Privada Hosp Asil Granollers, Serv Neurol Unitat Trastorns Moviment, Barcelona, Spain

[12] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain

[13] Fundacio Catalana Sindrome Down, Barcelona Down Med Ctr, Barcelona, Spain

来源：

NPJ PARKINSONS DISEASE | 2025年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

PRODROMAL PARKINSONS-DISEASE; NEUROFILAMENT LIGHT-CHAIN; MDS RESEARCH CRITERIA; NEURODEGENERATION; DEMENTIA; RISK; ASSOCIATION; DIFFUSIVITY; DIAGNOSIS;

D O I：

10.1038/s41531-025-01058-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. Its relationship with cortical thickness (CTh), clinical features, and neuropsychological performance is also unknown. We assessed cMD and CTh in thirty-six patients with iRBD at high risk of conversion and 29 healthy controls (HC), examining associations with clinical and cognitive measures. Effect sizes were calculated using Cohen's d. Patients with iRBD showed increased cMD in rostral and caudal cortical regions compared to HC (d > 0.5). Cortical thinning was restricted to caudal areas. Higher cMD correlated with longer iRBD duration, later onset, MDS-UPDRS III, apathy, and poorer performance on Grooved Pegboard and Symbol-Digit Modality Tests. These findings suggest that cMD may be more sensitive than CTh and serve as a valuable imaging biomarker for detecting early cortical changes in prodromal LB diseases.

引用

页数：10

共 77 条

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