The Role of the Immune Microenvironment on Osteoblast Differentiation

被引：0

作者：

Wang, Mengtao ^{[1
]}

Cao, Zhicheng ^{[1
]}

Hu, Wenhui ^{[1
]}

Dong, Zhiwen ^{[1
]}

Wang, Yufeng ^{[1
]}

Ma, Changyan ^{[2
]}

Tang, Cheng ^{[1
]}

机构：

[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Orthoped, 68 Changle Rd, Nanjing 210006, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Sch Basic Med Sci, Dept Med Genet, 101 Longmian Ave, Nanjing 211166, Peoples R China

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2025年

关键词：

Immune microenvironment; osteoblast differentiation; cytokine; immune cell; osteoimmunology; MESENCHYMAL STEM-CELLS; REGULATORY T-CELLS; TGF-BETA; BONE-FORMATION; RHEUMATOID-ARTHRITIS; KNEE OSTEOARTHRITIS; IN-VITRO; GROWTH; OSTEOGENESIS; EXPRESSION;

D O I：

10.1080/08820139.2025.2527246

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Osteoblasts, derived from mesenchymal stem cells (MSCs) in the bone marrow, are responsible for bone formation. Osteoblast differentiation is orchestrated by a spectrum of biological signals, with immune-derived components serving as indispensable regulators in this network. Dysfunctional osteoblast differentiation underlies bone-related pathologies such as osteoarthritis, rheumatoid arthritis, and osteoporosis, where immune dysregulation drives inflammatory cascades that disrupt the osteoblast-osteoclast equilibrium. This bidirectional crosstalk has propelled the emergence of osteoimmunology as a pivotal discipline.Methods: By analyzing immune cells and cytokines in the immune microenvironment, we synthesize evidence on their roles in regulating osteoblast differentiation, with focus on inflammatory bone disorders, particularly in osteoarthritis.Results: Thus, bone growth, development, and healing are intrinsically coupled with the dynamics of the immune microenvironment, which contributes to subchondral bone sclerosis and disease progression in osteoarthritis. Therefore, targeting immune-osteoblast crosstalk offers therapeutic potential for bone pathologies.Conclusion: This review consolidates recent advances in understanding how the immune microenvironment impacts osteoblast differentiation, aiming to provide novel insights for clinical strategies targeting bone repair and disease mitigation.

引用

页数：50

共 268 条

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