The evolution of analytical techniques for multiplex analysis of protein biomarkers

被引：0

作者：

Kim, Hyeyoon ^{[1
]}

Hall, David Ross ^{[1
]}

Nierves, Lorenz ^{[1
]}

Lin, Tai-Tu ^{[1
]}

Kitata, Reta Birhanu ^{[1
]}

Shi, Tujin ^{[1
]}

Liu, Tao ^{[1
]}

机构：

[1] Pacific Northwest Natl Lab, Biol Sci Div, Richland, WA USA

来源：

EXPERT REVIEW OF PROTEOMICS | 2025年 / 22卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Proteomics; multiplex analysis; protein biomarkers; biomarker development; mass spectrometry; MASS-SPECTROMETRY; DYNAMIC-RANGE; IMMUNO-PCR; PROTEOMICS; DISCOVERY; REVEALS; ANTIBODIES; LANDSCAPE; ROBUST; ASSAY;

D O I：

10.1080/14789450.2025.2529185

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

IntroductionThe landscape of biomarker development has evolved with advanced analytical technologies, particularly affinity- and mass spectrometry-based techniques. These advancements have deepened our understanding of disease mechanisms, enabling the development of precise diagnostic tools and personalized medicine. Protein biomarkers, which play pivotal roles in biological processes, have become invaluable in diagnosing and monitoring diseases, aided by their presence in various biological samples and the availability of established detection methods.Areas coveredThis review covers the role of protein biomarkers in clinical practice, the development and dimensionality of protein biomarkers, advancements in detection technologies, a comparison of these technologies, and future directions in biomarker discovery and disease mechanism elucidation.Expert opinionAdvances in biomarker technologies have the potential to transform diagnostics and personalized treatment but face challenges such as high costs and technical complexity. Enhancing reproducibility and integrating multi-omics approaches may offer better insights. The field should evolve toward high-throughput, automated methods, continuously adapting research, and clinical practices.

引用

页码：255 / 272

页数：18

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