Molecular and clinical insights into early-onset endometrial cancer

被引：0

作者：

Wu, Zimeng ^{[1
,2
]}

Hu, Zhe ^{[1
,2
]}

Li, Qinlan ^{[1
,2
]}

Liu, Geyan ^{[2
]}

Oaknin, Ana ^{[3
]}

Bejar, Juan Francisco Grau ^{[3
]}

Mills, Gordon B. ^{[4
]}

Ma, Ding ^{[1
,2
]}

Sun, Chaoyang ^{[1
,2
]}

Chen, Gang ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gynecol Oncol, Wuhan, Peoples R China

[2] Huazhong Univ Sci & Technol, Natl Clin Res Ctr Obstet & Gynecol, Canc Biol Res Ctr, Key Lab Minist Educ,Tongji Hosp,Tongji Med Coll, Wuhan, Peoples R China

[3] Vall dHebron Barcelona Hosp Campus, Vall dHebron Inst Oncol, Med Oncol Serv, Barcelona, Spain

[4] OHSU Knight Canc Inst, Portland, OR USA

来源：

TRENDS IN CANCER | 2025年 / 11卷 / 06期

关键词：

FERTILITY-PRESERVING TREATMENT; DNA MISMATCH-REPAIR; BODY-MASS INDEX; QUALITY-OF-LIFE; WOMEN; 40; YEARS; LYNCH SYNDROME; SPARING TREATMENT; YOUNG-WOMEN; MEDROXYPROGESTERONE ACETATE; SEXUAL-ACTIVITY;

D O I：

10.1016/j.trecan.2025.03.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The global incidence of endometrial cancer is on the rise, marked by a notable surge in early-onset endometrial cancer (EOEC; age at diagnosis <50 years). By contrast to late-onset cases, EOEC displays distinct clinical, pathological, and molecular characteristics. The enhanced understanding of the disease's patho-physiology, enabling a more precise differentiation between low-risk and high-risk patients, could facilitate the establishment of risk-stratified treatments that preserve ovarian function and fertility in low-risk EOEC cases. In this review, we delve into the distinctive epidemiological, molecular, and clinical characteris-tics of EOEC, as well as early noninvasive screening and fertility preservation treatments.

引用

页码：503 / 519

页数：17

共 181 条

[1] Patient and provider factors associated with endometrial Pipelle sampling failure [J].

Adambekov, Shalkar ;

Goughnour, Sharon L. ;

Mansuria, Suketu ;

Donnellan, Nicole ;

Elishaev, Esther ;

Villanueva, Hugo J. ;

Edwards, Robert P. ;

Bovbjerg, Dana H. ;

Linkov, Faina .

GYNECOLOGIC ONCOLOGY, 2017, 144 (02) :324-328

[2] Association between early life exposure to agriculture, biodiversity, and green space and risk of in fl ammatory bowel disease: a population-based cohort study [J].

Agrawal, Manasi ;

Hansen, Anne, V ;

Colombel, Jean-Frederic ;

Jess, Tine ;

Allin, Kristine H. .

ECLINICALMEDICINE, 2024, 70

[3] Overexpressed Epidermal Growth Factor Receptor (EGFR)-Induced Progestin Insensitivity in Human Endometrial Carcinoma Cells by the EGFR/Mitogen-Activated Protein Kinase Signaling Pathway [J].

Ai, Zhihong ;

Wang, Juan ;

Wang, Yudong ;

Lu, Lihua ;

Tong, Jianqian ;

Teng, Yincheng .

CANCER, 2010, 116 (15) :3603-3613

[4] Risk of endometrial cancer in relationship to cigarette smoking:: Results from the EPIC study [J].

AI-Zoughool, Mustafa ;

Dossus, Laure ;

Kaaks, Rudolf ;

Clavel-Chapelon, Francoise ;

Tjormeland, Anne ;

Olsen, Anja ;

Overvad, Kim ;

Boutron-Ruault, Marie-Christine ;

Gauthier, Estelle ;

Linseisen, Jakob ;

Chang-Claude, Jenny ;

Boeing, Heiner ;

Schulz, Mandy ;

Trichopoulou, Antonia ;

Chryssa, Travezea ;

Trichopoulos, Dimitrios ;

Berrino, Franco ;

Pallilo, Domenico ;

Mattiello, Amalia ;

Tumino, Rosario ;

Sacerdote, Carlotta ;

Bueno-de-Mesquita, H. Bas ;

Boshuizen, Hendrick C. ;

Peeters, Petra H. M. ;

Gram, Inger T. ;

Braaten, Tonje ;

Lund, Eiliv ;

Chirlaque, Maria-Dolores ;

Ardanaz, Eva ;

Agudo, Antonio ;

Larrañaga, Nerea ;

Quirós, Jose Ramon ;

Berglund, Goran ;

Manjer, Jonas ;

Lundin, Eva ;

Halmans, Goran ;

Khaw, Kay-Tee ;

Bingham, Sheila ;

Allen, Naomi ;

Key, Tim ;

Jenab, Mazda ;

Cust, Anne E. ;

Rinaldi, Sabina ;

Riboli, Elio .

INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (12) :2741-2747

[5]

[Anonymous], 2014, Obstet Gynecol, V124, P1042, DOI 10.1097/01.AOG.0000456325.50739.72

[6] Endometrial cancer survivors' sleep patterns before and after a physical activity intervention: A retrospective cohort analysis [J].

Armbruster, Shannon D. ;

Song, Jaejoon ;

Gatus, Leticia ;

Lu, Karen H. ;

Basen-Engquist, Karen M. .

GYNECOLOGIC ONCOLOGY, 2018, 149 (01) :133-139

[7] High-Sensitivity Mutation Analysis of Cell-Free DNA for Disease Monitoring in Endometrial Cancer [J].

Ashley, Charles W. ;

Selenica, Pier ;

Patel, Juber ;

Wu, Michelle ;

Nincevic, Josip ;

Lakhman, Yulia ;

Zhou, Qin ;

Shah, Ronak H. ;

Berger, Michael F. ;

Paula, Arnaud Da Cruz ;

Brown, David N. ;

Marra, Antonio ;

Iasonos, Alexia ;

Momeni-Boroujeni, Amir ;

Alektiar, Kaled M. ;

Roche, Kara Long ;

Zivanovic, Oliver ;

Mueller, Jennifer J. ;

Zamarin, Dmitriy ;

Broach, Vance A. ;

Sonoda, Yukio ;

Leitao Jr, Mario M. ;

Friedman, Claire F. ;

Jewell, Elizabeth ;

Reis-Filho, Jorge S. ;

Ellenson, Lora H. ;

Aghajanian, Carol ;

Abu-Rustum, Nadeem R. ;

Cadoo, Karen ;

Weigelt, Britta .

CLINICAL CANCER RESEARCH, 2023, 29 (02) :410-421

[8] Quantifying procedural pain associated with office gynecologic tract sampling methods* [J].

Bagaria, Madhu ;

Wentzensen, Nicolas ;

Clarke, Megan ;

Hopkins, Matthew R. ;

Ahlberg, Lisa J. ;

Mc Guire, Lois J. ;

Lemens, Maureen A. ;

Weaver, Amy L. ;

VanOosten, Ann ;

Shields, Emily ;

Laughlin-Tommaso, Shannon K. ;

Sherman, Mark E. ;

Bakkum-Gamez, Jamie N. .

GYNECOLOGIC ONCOLOGY, 2021, 162 (01) :128-133

[9] Detection of endometrial cancer using tampon-based collection and methylated DNA markers* [J].

Bakkum-Gamez, Jamie N. ;

Sherman, Mark E. ;

Slettedahl, Seth W. ;

Mahoney, Douglas W. ;

Lemens, Maureen A. ;

Laughlin-Tommaso, Shannon K. ;

Hopkins, Matthew R. ;

VanOosten, Ann ;

Shridhar, Viji ;

Staub, Julie K. ;

Cao, Xiaoming ;

Foote, Patrick H. ;

Clarke, Megan A. ;

Burger, Kelli N. ;

Berger, Calise K. ;

O'Connell, Maria C. ;

Doering, Karen A. ;

Podratz, Karl C. ;

DeStephano, Christopher C. ;

Schoolmeester, J. Kenneth ;

Kerr, Sarah E. ;

Wentzensen, Nicolas ;

Taylor, William R. ;

Kisiel, John B. .

GYNECOLOGIC ONCOLOGY, 2023, 174 :11-20

[10] Detection of endometrial cancer via molecular analysis of DNA collected with vaginal tampons [J].

Bakkum-Gamez, Jamie N. ;

Wentzensen, Nicolas ;

Maurer, Matthew L. ;

Hawthorne, Kieran M. ;

Voss, Jesse S. ;

Kroneman, Trynda N. ;

Famuyide, Abimbola O. ;

Clayton, Amy C. ;

Hailing, Kevin C. ;

Kerr, Sarah E. ;

Cliby, William A. ;

Dowdy, Sean C. ;

Kipp, Benjamin R. ;

Mariani, Andrea ;

Oberg, Ann L. ;

Podratz, Karl C. ;

Shridhar, Viji ;

Sherman, Mark E. .

GYNECOLOGIC ONCOLOGY, 2015, 137 (01) :14-22

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