Preventive effects of polyphenols from Insect tea on acetaminophen-induced hepatic injury in ICR mice

被引：0

作者：

Sun P. ^{[1
]}

Feng X. ^{[1
]}

Yi R. ^{[1
]}

Zhao X. ^{[1
]}

机构：

[1] Chongqing Engineering Laboratory for Research and Development of Functional Food, Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing

来源：

Shipin Kexue/Food Science | 2016年 / 37卷 / 21期

关键词：

Acetaminophen; Expression; Hepatic injury; Insect tea; Polyphenol;

D O I：

10.7506/spkx1002-6630-201621044

中图分类号：

学科分类号：

摘要：

The purpose of this study was to investigate the preventive effects of crude polyphenols from Insect tea (CPIT) on hepatic damage induced by acetaminophen in ICR mice. CPIT could increase body weight and reduce liver weight and liver index after induction of liver injury in mice. Serum levels of alanine aminotransferase, aspartate aminotransferase, lacate dehydrogenase, triglycerides, and blood urea nitrogen were decreased, while total cholesterol and albumin were increased in mice treated with CPIT as compared with liver injury controls. CPIT also resulted in a reduction in IL (interleukin)-6, IL-12, TNF (tumor necrosis factor)-α and IFN (interferon)-γ in comparison with control mice. It could increase the mRNA expression of IκB-α, Mn-SOD, Cu/Zn-SOD, CAT and GSH-Px, and decrease the mRNA expression of NF-κB, iNOS and COX-2. From the above findings, we can conclude that CPIT has a preventive effect on hepatic injury in vivo. © 2016, China Food Publishing Company. All right reserved.

引用

页码：257 / 264

页数：7

共 33 条

[1]

Zhao X., Wang Q., Li G.J., Et al., In vitro antioxidant, anti-mutagenic, anti-cancer and anti-angiogenic effects of Chinese bowl tea, Journal of Fucntional Foods, 7, pp. 590-598, (2014)

[2]

Feng X., Luo M., Zhao X., Inbibitional effect of sandy tea on the carcinoma cells growth and tumor metastasis, Modern Food Science and Technology, 29, 8, pp. 1898-1901, (2013)

[3]

Zhou Y.L., Wang R., Feng X., Et al., Preventive effect of insect tea against reserpine-induced gastric ulcers in mice, Experimental and Therapeutic Medicine, 8, 4, pp. 1318-1324, (2014)

[4]

Zhao X., Wang R., Qian Y., Et al., In vivo preventive effects of insect tea on buccal mucosa cancer in ICR mice, Journal of Cancer Research and Therapeutics, 10, 3, pp. 651-657, (2014)

[5]

Zhen M.C., Wang Q., Huang X.H., Et al., Green tea polyphenol epigallocatechin-3-gallate inhibits oxidative damage and preventive effects on carbon tetrachloride-induced hepatic fibrosis, Journal of Nutritional Biochemistry, 18, 12, pp. 795-805, (2007)

[6]

El-Beshbishy H.A., Tork O.M., El-Bab M.F., Et al., Antioxidant and antiapoptotic effects of green tea polyphenols against azathioprineinduced liver injury in rats, Pathophysiology, 18, 2, pp. 125-135, (2011)

[7]

Xu G.M., Peng X.J., Wang C.J., Et al., Extraction of polyphenols in aglossa dimidiata with ions Al3+and Zn<sup>2+</sup> sedimentation, Journal of Traditional Chinese Medicine University of Hunan, 27, 2, pp. 46-48, (2007)

[8]

He B.H., Study on extraction techniques of trilobite tea polyphenols, Journal of Hunan Ecological Science, 1, 4, pp. 40-44, (2014)

[9]

Krenkel O., Mossanen J.C., Tacke F., Immune mechanisms in acetaminophen-induced acute liver failure, Hepatobiliary Surgery and Nutrition, 3, 6, pp. 331-343, (2014)

[10]

Olaleye M.T., Amobonye A.E., Komolafe K., Et al., Protective effects of Parinari curatellifolia flavonoids against acetaminopheninduced hepatic necrosis in rats, Saudi Journal of Biological Sciences, 21, 5, pp. 486-492, (2014)

← 1 2 3 4 →