Changes of autophagy related proteins during sublingual immunotherapy treatment in allergic rhinitis

被引：0

作者：

Wang, Chunrui ^{[1
]}

Jiang, Li ^{[1
]}

Qin, Xiaowei ^{[1
]}

Zhang, Tianhong ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Harbin 150001, Heilongjiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | 2025年 / 196卷

关键词：

Allergic rhinitis; Sublingual immunotherapy; Autophagy; ATG5; p62; Beclin-1; LC3I; LC3II; TIGHT JUNCTION PROTEINS; PREVALENCE; ASTHMA;

D O I：

10.1016/j.ijporl.2025.112477

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: Allergic rhinitis (AR) affects the nasal mucosa, causing significant quality of life impairments. Sublingual immunotherapy (SLIT) is effective in mitigating AR symptoms. Autophagy regulates immune responses and is implicated in AR. We aimed to investigate the impact of SLIT on autophagy-associated proteins and their relationship with Th1 and Th2 cytokines in AR patients. Methods: Sixty AR children were recruited. They underwent standardized SLIT with Der f extract. Efficacy was evaluated using combined symptom and medication score (CSMS). Blood samples were analyzed for autophagyrelated proteins (ATG5, p62, Beclin-1, LC3I, LC3II) and Th1/Th2 cytokines (IFN-gamma, IL-4). Results: After 3 years' SLIT, ATG5, LC3I, LC3II, and Beclin-1 expressions decreased, while p62 increased. Th1 cytokine expression increased, and Th2 cytokine expression decreased. The effective group showed greater changes in protein expression compared to the ineffective group. A positive correlation was found between autophagy-associated protein expression and Th2 cytokines. Conclusion: SLIT alters autophagy-related protein levels and reverses the Th1/Th2 balance in AR patients, suggesting autophagy-associated proteins as potential biomarkers for SLIT efficacy.

引用

页数：4

共 30 条

[1] Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report [J].

Bacharier, L. B. ;

Boner, A. ;

Carlsen, K. -H. ;

Eigenmann, P. A. ;

Frischer, T. ;

Goetz, M. ;

Helms, P. J. ;

Hunt, J. ;

Liu, A. ;

Papadopoulos, N. ;

Platts-Mills, T. ;

Pohunek, P. ;

Simons, F. E. R. ;

Valovirta, E. ;

Wahn, U. ;

Wildhaber, J. .

ALLERGY, 2008, 63 (01) :5-34

[2] Costs associated with persistent allergic rhinitis are reduced by levocetirizine [J].

Bousquet, J ;

Demarteau, N ;

Mullol, J ;

van den Akker-van Marle, ME ;

Van Ganse, E ;

Bachert, C .

ALLERGY, 2005, 60 (06) :788-794

[3] Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision [J].

Brozek, Jan L. ;

Bousquet, Jean ;

Agache, Ioana ;

Agarwal, Arnav ;

Bachert, Claus ;

Bosnic-Anticevich, Sinthia ;

Brignardello-Petersen, Romina ;

Canonica, G. Walter ;

Casale, Thomas ;

Chavannes, Niels H. ;

de Sousa, Jaime Correia ;

Cruz, Alvaro A. ;

Cuello-Garcia, Carlos A. ;

Demoly, Pascal ;

Dykewicz, Mark ;

Etxeandia-Ikobaltzeta, Itziar ;

Florez, Ivan D. ;

Fokkens, Wytske ;

Fonseca, Joao ;

Hellings, Peter W. ;

Klimek, Ludger ;

Kowalski, Sergio ;

Kuna, Piotr ;

Laisaar, Kaja-Triin ;

Larenas-Linnemann, Desiree E. ;

Carlsen, Karin C. Lodrup ;

Manning, Peter J. ;

Meltzer, Eli ;

Mullol, Joaquim ;

Muraro, Antonella ;

O'Hehir, Robyn ;

Ohta, Ken ;

Panzner, Petr ;

Papadopoulos, Nikolaos ;

Park, Hae-Sim ;

Passalacqua, Gianni ;

Pawankar, Ruby ;

Price, David ;

Riva, John J. ;

Roldan, Yetiani ;

Ryan, Dermot ;

Sadeghirad, Behnam ;

Samolinski, Boleslaw ;

Schmid-Grendelmeier, Peter ;

Sheikh, Aziz ;

Togias, Alkis ;

Valero, Antonio ;

Valiulis, Arunas ;

Valovirta, Erkka ;

Ventresca, Matthew .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (04) :950-958

[4] Patient Perceptions of Allergic Rhinitis and Quality of Life Findings From a Survey Conducted in Europe and the United States [J].

Canonica, G. Walter ;

Mullol, Joaquim ;

Pradalier, Andre ;

Didier, Alain .

WORLD ALLERGY ORGANIZATION JOURNAL, 2008, 1 :138-144

[5] Sublingual immunotherapy of house dust mite respiratory allergy in China [J].

Cheng, L. ;

Zhou, W. -C. .

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, 2019, 47 (01) :85-89

[6]

Choi AMK, 2013, NEW ENGL J MED, V368, P1845, DOI [10.1056/NEJMra1205406, 10.1056/NEJMc1303158]

[7] Sublingual immunotherapy: A comprehensive review [J].

Cox, Linda S. ;

Linnemann, Desiree Larenas ;

Nolte, Hendrik ;

Weldon, David ;

Finegold, Ira ;

Nelson, Harold S. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (05) :1021-1035

[8] Long-Term Efficacy of Sublingual Mite Immunotherapy in Monosensitized and Polysensitized Children with Allergic Rhinitis: A 7-Year Prospective Study [J].

Cui, Long ;

Li, Jun ;

Li, Yong ;

Xia, Zhongfang .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2019, 180 (02) :144-149

[9] BECN2 (beclin 2) Negatively Regulates Inflammasome Sensors Through ATG9A-Dependent but ATG16L1-and LC3-Independent Non-Canonical Autophagy [J].

Deng, Guangtong ;

Li, Chaoran ;

Chen, Lang ;

Xing, Changsheng ;

Fu, Chuntang ;

Qian, Chen ;

Liu, Xin ;

Wang, Helen Y. ;

Zhu, Motao ;

Wang, Rong-Fu .

AUTOPHAGY, 2022, 18 (02) :340-356

[10] Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function [J].

Galle-Treger, Lauriane ;

Hurrell, Benjamin P. ;

Lewis, Gavin ;

Howard, Emily ;

Jahani, Pedram Shafiei ;

Banie, Homayon ;

Razani, Babak ;

Soroosh, Pejman ;

Akbari, Omid .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 145 (02) :502-+

← 1 2 3 →