At last: the mitochondrial pyruvate carrier structure revealed

被引：0

作者：

Finck, Brian N. ^{[1
]}

Hadfield, Christy M. ^{[2
]}

McCommis, Kyle S. ^{[2
]}

机构：

[1] Washington Univ, Ctr Human Nutr, Sch Med, Dept Med,Div Nutr Sci & Obes Med, St Louis, MO 63110 USA

[2] St Louis Univ, Sch Med, Edward A Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2025年 / 46卷 / 07期

关键词：

IDENTIFICATION;

D O I：

10.1016/j.ips20025.05.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mitochondrial pyruvate carrier (MPC) inhibitors have shown promise as therapeutics for treating several chronic diseases. However, the structure of MPC and the molecular mechanisms by which it interacts with inhibitors have remained un-clear, impeding rational drug design. Multiple groups have now indepen-dently resolved the structure of the MPC heterodimer.

引用

页码：596 / 598

页数：3

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