Clonal hematopoiesis in myeloid malignancies and solid tumors

被引：0

作者：

Cai, Xiurong ^{[1
]}

Bowman, Robert L. ^{[2
]}

Trowbridge, Jennifer J. ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

[2] Univ Penn, Perelman Sch Med, Dept Canc Biol, Philadelphia, PA 19104 USA

来源：

NATURE CANCER | 2025年 / 6卷 / 07期

基金：

美国国家卫生研究院;

关键词：

STEM-CELL DONORS; SOMATIC MUTATIONS; RESIDUAL DISEASE; PPM1D MUTATIONS; BONE-MARROW; AGE; LEUKEMIA; COMMON; BLOOD; RISK;

D O I：

10.1038/s43018-025-01014-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clonal hematopoiesis (CH) results from clonal expansion of hematopoietic stem cells. In specific contexts, CH is linked with an increased risk of blood cancers and mortality in individuals with solid tumors. To understand the mechanisms and clinical relevance of this association, it is crucial to explore the reciprocal relationship between CH and cancer. Here, we provide an updated summary of the mechanisms known to drive CH in blood cancers and solid tumors. In addition, we review proposed strategies to intercept CH and examine their impact on solid tumor-directed therapies, including immunostimulatory therapies.

引用

页码：1133 / 1144

页数：12

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