Clonal hematopoiesis in myeloid malignancies and solid tumors

被引：0

作者：

Cai, Xiurong ^{[1
]}

Bowman, Robert L. ^{[2
]}

Trowbridge, Jennifer J. ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

[2] Univ Penn, Perelman Sch Med, Dept Canc Biol, Philadelphia, PA 19104 USA

来源：

NATURE CANCER | 2025年 / 6卷 / 07期

基金：

美国国家卫生研究院;

关键词：

STEM-CELL DONORS; SOMATIC MUTATIONS; RESIDUAL DISEASE; PPM1D MUTATIONS; BONE-MARROW; AGE; LEUKEMIA; COMMON; BLOOD; RISK;

D O I：

10.1038/s43018-025-01014-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clonal hematopoiesis (CH) results from clonal expansion of hematopoietic stem cells. In specific contexts, CH is linked with an increased risk of blood cancers and mortality in individuals with solid tumors. To understand the mechanisms and clinical relevance of this association, it is crucial to explore the reciprocal relationship between CH and cancer. Here, we provide an updated summary of the mechanisms known to drive CH in blood cancers and solid tumors. In addition, we review proposed strategies to intercept CH and examine their impact on solid tumor-directed therapies, including immunostimulatory therapies.

引用

页码：1133 / 1144

页数：12

共 120 条

[1] An inflammatory environment containing TNFα favors Tet2-mutant clonal hematopoiesis [J].

Abegunde, Samuel O. ;

Buckstein, Rena ;

Wells, Richard A. ;

Rauh, Michael J. .

EXPERIMENTAL HEMATOLOGY, 2018, 59 :60-65

[2] Prediction of acute myeloid leukaemia risk in healthy individuals [J].

Abelson, Sagi ;

Collord, Grace ;

Ng, Stanley W. K. ;

Weissbrod, Omer ;

Cohen, Netta Mendelson ;

Niemeyer, Elisabeth ;

Barda, Noam ;

Zuzarte, Philip C. ;

Heisler, Lawrence ;

Sundaravadanam, Yogi ;

Luben, Robert ;

Hayat, Shabina ;

Wang, Ting Ting ;

Zhao, Zhen ;

Cirlan, Julia ;

Pugh, Trevor J. ;

Soave, David ;

Ng, Karen ;

Latimer, Calli ;

Hardy, Claire ;

Raine, Keiran ;

Jones, David ;

Hoult, Diana ;

Britten, Abigail ;

McPherson, John D. ;

Johansson, Mattias ;

Mbabaali, Faridah ;

Eagles, Jenna ;

Millers, Jessica K. ;

Pasternack, Danielle ;

Timms, Lee ;

Krzyzanowski, Paul ;

Awadalla, Philip ;

Costa, Rui ;

Segal, Eran ;

Bratman, Scott, V ;

Beer, Philip ;

Behjati, Sam ;

Martincorena, Inigo ;

Wang, Jean C. Y. ;

Bowles, Kristian M. ;

Ramon Quiros, J. ;

Karakatsani, Anna ;

La Vecchia, Carlo ;

Trichopoulou, Antonia ;

Salamanca-Fernandez, Elena ;

Huerta, Jose M. ;

Barricarte, Aurelio ;

Travis, Ruth C. ;

Tumino, Rosario .

NATURE, 2018, 559 (7714) :400-+

[3] Assessment of Tumor Mutational Burden and Outcomes in Patients With Diverse Advanced Cancers Treated With Immunotherapy [J].

Aggarwal, Charu ;

Ben-Shachar, Rotem ;

Gao, Yinjie ;

Hyun, Seung Won ;

Rivers, Zachary ;

Epstein, Carrie ;

Kaneva, Kristiyana ;

Sangli, Chithra ;

Nimeiri, Halla ;

Patel, Jyoti .

JAMA NETWORK OPEN, 2023, 6 (05)

[4] Efficacy and tolerability of isocitrate dehydrogenase inhibitors in patients with acute myeloid leukemia: A systematic review of clinical trials [J].

Aiman, Wajeeha ;

Ali, Muhammad Ashar ;

Basit, Muhammad Abdul ;

Omar, Zainab ;

Suleman, Muhammad ;

Hassan, Muhammad ;

Jamil, Taimoor ;

Anwar, Muhammad Saad ;

Shafique, Zubair ;

Dhanesar, Gurneel ;

Faisal, Muhammad Salman ;

Akerman, Michael J. ;

Maroules, Michael ;

Anwer, Faiz .

LEUKEMIA RESEARCH, 2023, 129

[5] Pervasive lesion segregation shapes cancer genome evolution [J].

Aitken, Sarah J. ;

Anderson, Craig J. ;

Connor, Frances ;

Pich, Oriol ;

Sundaram, Vasavi ;

Feig, Christine ;

Rayner, Tim F. ;

Lukk, Margus ;

Aitken, Stuart ;

Luft, Juliet ;

Kentepozidou, Elissavet ;

Arnedo-Pac, Claudia ;

Beentjes, Sjoerd V. ;

Davies, Susan E. ;

Drews, Ruben M. ;

Ewing, Ailith ;

Kaiser, Vera B. ;

Khamseh, Ava ;

Lopez-Arribillaga, Erika ;

Redmond, Aisling M. ;

Santoyo-Lopez, Javier ;

Sentis, Ines ;

Talmane, Lana ;

Yates, Andrew D. ;

Semple, Colin A. ;

Lopez-Bigas, Nuria ;

Flicek, Paul ;

Odom, Duncan T. ;

Taylor, Martin S. .

NATURE, 2020, 583 (7815) :265-+

[6] 60 Years of clonal hematopoiesis research: From X- chromosome inactivation studies to the identification of driver mutations [J].

Ayachi, Sami ;

Buscarlet, Manuel ;

Busque, Lambert .

EXPERIMENTAL HEMATOLOGY, 2020, 83 :2-11

[7] Targeting Immune Signaling Pathways in Clonal Hematopoiesis [J].

Azrakhsh, Nessar Ahmad ;

Mensah-Glanowska, Patrycja ;

Sand, Kristoffer ;

Kittang, Astrid Olsnes .

CURRENT MEDICINAL CHEMISTRY, 2019, 26 (28) :5262-5277

[8] Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis [J].

Bernstein, Nicholas ;

Spencer Chapman, Michael ;

Nyamondo, Kudzai ;

Chen, Zhenghao ;

Williams, Nicholas ;

Mitchell, Emily ;

Campbell, Peter J. ;

Cohen, Robert L. ;

Nangalia, Jyoti .

NATURE GENETICS, 2024, 56 (06) :1147-1155

[9] NORMAL HUMAN FEMALE AS A MOSAIC OF X-CHROMOSOME ACTIVITY - STUDIES USING GENE FOR G-6-PD-DEFICIENCY AS A MARKER [J].

BEUTLER, E ;

FAIRBANKS, VF ;

YEH, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1962, 48 (01) :9-&

[10] Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation [J].

Biechonski, Shahar ;

Olender, Leonid ;

Zipin-Roitman, Adi ;

Yassin, Muhammad ;

Aqaqe, Nasma ;

Marcu-Malina, Victoria ;

Rall-Scharpf, Melanie ;

Trottier, Magan ;

Meyn, M. Stephen ;

Wiesmueller, Lisa ;

Beider, Katia ;

Raz, Yael ;

Grisaru, Dan ;

Nagler, Arnon ;

Milyavsky, Michael .

SCIENTIFIC REPORTS, 2018, 8

← 1 2 3 4 5 6 7 8 9 10 →