Synthesis and Biological Activity of Benzoselenazole and Benzo[b]Selenophene Analogues: A Review

被引：0

作者：

Li, Jia ^{[1
]}

Chen, Jingmin ^{[1
]}

Liu, Jiayao ^{[1
]}

Zhou, Xudong ^{[1
,2
]}

Li, Yangyang ^{[1
,2
]}

Wang, Wei ^{[1
,2
]}

Sheng, Wenbing ^{[1
,2
]}

机构：

[1] Hunan Univ Chinese Med, Sch Pharm, Changsha, Peoples R China

[2] Hunan Univ Chinese Med, TCM & Ethnomedicine Innovat & Dev Int Lab, Changsha, Peoples R China

来源：

DRUG DEVELOPMENT RESEARCH | 2025年 / 86卷 / 05期

基金：

中国国家自然科学基金;

关键词：

biological activity; heterocycle; selenium; synthesis; HIGHLY EFFICIENT SYNTHESIS; ONE-POT SYNTHESIS; EBSELEN; CYCLIZATION; DERIVATIVES; ANTIOXIDANT; SELENIUM; SITE;

D O I：

10.1002/ddr.70127

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Selenium, an essential micronutrient in the human body, not only exhibits potent antioxidant properties but also plays a critical role in regulating thyroid hormone metabolism, maintaining normal immune function, and inhibiting tumour progression. Among selenium-containing compounds, ebselen is the most extensively studied drug candidate. Research has shown that various derivatives obtained through structural modifications of Ebselen exhibits significant biological activities; however, these compounds have yet to progress to clinical trials. Consequently, selenium-containing heterocyclic compounds represent a promising avenue for drug discovery and development. This review summarizes three synthetic approaches for constructing selenium-containing heterocyclic compounds and emphasizes their notable biological activities and potential applications in pharmaceuticals.

引用

页数：22

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