Prediction of systemic exposure by food effect on a fixed-dose combination of linagliptin and metformin extended-release

被引：0

作者：

Jeon, Jihyun ^{[1
]}

Jeon, Jiyeon ^{[1
]}

Yun, Hwi-yeol ^{[1
,2
,3
]}

Lee, Soyoung ^{[1
]}

Chae, Jung-woo ^{[1
,2
,3
]}

Kim, Jaewoo ^{[4
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, 99,Daehak Ro, Daejeon 34134, South Korea

[2] Chungnam Natl Univ, Sr Hlth Convergence Res Ctr, Daejeon, South Korea

[3] Chungnam Natl Univ, Dept BioAI Convergence, Daejeon, South Korea

[4] Yangji Hosp, Seoul, South Korea

来源：

DIABETES OBESITY & METABOLISM | 2025年

基金：

新加坡国家研究基金会;

关键词：

antidiabetic drug; linagliptin; metformin; pharmacokinetics; population study;

D O I：

10.1111/dom.16564

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：4

共 9 条

[1]

accessdata, Clinical pharmacology and biopharmaceutics review(s)

[2] Concept of Pharmacologic Target-Mediated Drug Disposition in Large-Molecule and Small-Molecule Compounds [J].

An, Guohua .

JOURNAL OF CLINICAL PHARMACOLOGY, 2020, 60 (02) :149-163

[3]

[Anonymous], FDA clinical pharmacology and biopharmaceutics review of Jentadueto XR

[4] Efficacy and Safety of Initial Combination Therapy in Treatment-Na⟨ve Type 2 Diabetes Patients: A Systematic Review and Meta-analysis [J].

Cai, Xiaoling ;

Gao, Xueying ;

Yang, Wenjia ;

Han, Xueyao ;

Ji, Linong .

DIABETES THERAPY, 2018, 9 (05) :1995-2014

[5] Combination of Linagliptin and Metformin for the Treatment of Patients with Type 2 Diabetes [J].

Haak, Thomas .

CLINICAL MEDICINE INSIGHTS-ENDOCRINOLOGY AND DIABETES, 2015, 8 :1-6

[6] Confidence and Prediction Intervals for Pharmacometric Models [J].

Kummel, Anne ;

Bonate, Peter L. ;

Dingemanse, Jasper ;

Krause, Andreas .

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2018, 7 (06) :360-373

[7] A retrospective study of persistence, adherence, and health economic outcomes of fixed-dose combination vs loose-dose combination of oral anti-diabetes drugs [J].

Lokhandwala, Tasneem ;

Smith, Nancy ;

Sternhufvud, Catarina ;

Sorstadius, Elisabeth ;

Lee, Won Chan ;

Mukherjee, Jayanti .

JOURNAL OF MEDICAL ECONOMICS, 2016, 19 (03) :203-212

[8]

mfds, Drug Approval Report of Newjenta CR tab

[9] Population Pharmacokinetics and Pharmacodynamics of Linagliptin in Patients with Type 2 Diabetes Mellitus [J].

Retlich, Silke ;

Duval, Vincent ;

Graefe-Mody, Ulrike ;

Friedrich, Christian ;

Patel, Sanjay ;

Jaehde, Ulrich ;

Staab, Alexander .

CLINICAL PHARMACOKINETICS, 2015, 54 (07) :737-750

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