Silent metastasis in metastatic castrate-resistant prostate cancer: a collection of two case reports

被引：0

作者：

De Felice, Francesca ^{[1
]}

Vitti, Elisa ^{[1
]}

Cattaneo, Carlo Guglielmo ^{[1
]}

Tomaciello, Miriam ^{[1
]}

Marampon, Francesco ^{[1
]}

Musio, Daniela ^{[1
]}

Gaudino, Chiara ^{[2
]}

Minniti, Giuseppe ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Radiol Oncol & Pathol Sci, AOU Policlin Umberto I, Radiat Oncol, Rome, Italy

[2] AOU Policlin Umberto I, Dept Neuroradiol, Rome, Italy

来源：

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2025年 / 43卷 / 06期

关键词：

Prostate cancer; PSA; PSA discordance; ARPI; metastasis; castrate-resistant; case report; ENZALUTAMIDE; MEN;

D O I：

10.1016/j.urolonc.2024.10.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment monitoring in metastatic castrate-resistant prostate cancer has become a hot topic in the androgen receptor pathway inhibitors (ARPIs) era. Patients without increase in their PSA level at the time of imaging progression are not a rare phenomenon. What is the best monitoring strategy in asymptomatic cases represents a salient question. Here we presented 2 case reports involving men with metastatic castration-resistant prostate cancer who experienced disease progression without the anticipated increase in PSA levels. Our 2 cases show that imaging beyond standard PSA determination should be incorporate to monitor disease progression in patients with metastatic castrate-resistant prostate cancer even in the context of an undetectable PSA. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

引用

页码：399.e9 / 399.e13

页数：5

共 17 条

[11] Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer [J].

Hussain, Maha ;

Fizazi, Karim ;

Saad, Fred ;

Rathenborg, Per ;

Shore, Neal ;

Ferreira, Ubirajara ;

Ivashchenko, Petro ;

Demirhan, Eren ;

Modelska, Katharina ;

Phung, De ;

Krivoshik, Andrew ;

Sternberg, Cora N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (26) :2465-2474

[12] Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy [J].

James, N. D. ;

de Bono, J. S. ;

Spears, M. R. ;

Clarke, N. W. ;

Mason, M. D. ;

Dearnaley, D. P. ;

Ritchie, A. W. S. ;

Amos, C. L. ;

Gilson, C. ;

Jones, R. J. ;

Matheson, D. ;

Miliman, R. ;

Attard, G. ;

Chowdhury, S. ;

Cross, W. R. ;

Gillessen, S. ;

Parker, C. C. ;

Russell, J. M. ;

Berthold, D. R. ;

Brawley, C. ;

Adab, F. ;

Aung, S. ;

Birtle, A. J. ;

Bowen, J. ;

Brock, S. ;

Chakraborti, P. ;

Ferguson, C. ;

Gale, J. ;

Gray, E. ;

Hingorani, M. ;

Hoskin, P. J. ;

Lester, J. F. ;

Malik, Z. I. ;

McKinna, F. ;

McPhail, N. ;

Money-Kyrle, J. ;

O'Sullivan, J. ;

Parikh, O. ;

Protheroe, A. ;

Robinson, A. ;

Srihari, N. N. ;

Thomas, C. ;

Wagstaff, J. ;

Wylie, J. ;

Zarkar, A. ;

Parmar, M. K. B. ;

Sydes, M. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (04) :338-351

[13] Updates to Advanced Prostate Cancer: AUA/SUO Guideline (2023) [J].

Lowrance, William ;

Dreicer, Robert ;

Jarrard, David F. ;

Scarpato, Kristen R. ;

Kim, Sennett K. ;

Kirkby, Erin ;

Buckley, David I. ;

Griffin, Jessica C. ;

Cookson, Michael S. .

JOURNAL OF UROLOGY, 2023, 209 (06) :1082-1090

[14]

National Comprehensive Cancer Network, 2023, Prostate Cancer

[15] Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up [J].

Parker, C. ;

Castro, E. ;

Fizazi, K. ;

Heidenreich, A. ;

Ost, P. ;

Procopio, G. ;

Tombal, B. ;

Gillessen, S. .

ANNALS OF ONCOLOGY, 2020, 31 (09) :1119-1134

[16] Apalutamide and Overall Survival in Prostate Cancer [J].

Smith, Matthew R. ;

Saad, Fred ;

Chowdhury, Simon ;

Oudard, Stephane ;

Hadaschik, Boris A. ;

Graff, Julie N. ;

Olmos, David ;

Mainwaring, Paul N. ;

Lee, Ji Youl ;

Uemura, Hiroji ;

De Porre, Peter ;

Smith, Andressa A. ;

Brookman-May, Sabine D. ;

Li, Susan ;

Zhang, Ke ;

Rooney, Brendan ;

Lopez-Gitlitz, Angela ;

Small, Eric J. .

EUROPEAN UROLOGY, 2021, 79 (01) :150-158

[17]

SungH FerlayJ, Globalcancerstatistics2020: GLOBOCANestimatesofincidenceandmortalityworldwidefor36cancersin185countries

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