Severity of atopic dermatitis is associated with gut-derived metabolites and leaky gut-related biomarkers

被引：0

作者：

Blicharz, Leszek ^{[1
]}

Samborowska, Emilia ^{[2
]}

Zagozdzon, Radoslaw ^{[3
]}

Bukowska-Osko, Iwona ^{[4
]}

Czuwara, Joanna ^{[1
]}

Zych, Michal ^{[5
]}

Roszczyk, Aleksander ^{[5
]}

Perlejewski, Karol ^{[4
]}

Makowska, Karolina ^{[1
]}

Nowaczyk, Joanna ^{[1
,6
]}

Zaremba, Michal ^{[1
]}

Kazimierska, Karolina ^{[1
]}

Waskiel-Burnat, Anna ^{[1
]}

Dadlez, Michal ^{[2
]}

Samochocki, Zbigniew ^{[1
]}

Olszewska, Malgorzata ^{[1
]}

Radkowski, Marek ^{[4
]}

Rudnicka, Lidia ^{[1
]}

机构：

[1] Med Univ Warsaw, Dept Dermatol, Nowogrodzka 59, PL-02006 Warsaw, Poland

[2] Polish Acad Sci, Inst Biochem & Biophys, Mass Spectrometry Lab, PL-02106 Warsaw, Poland

[3] Med Univ Warsaw, Lab Cellular & Genet Therapies, PL-02097 Warsaw, Poland

[4] Med Univ Warsaw, Dept Immunopathol Infect & Parasit Dis, PL-02106 Warsaw, Poland

[5] Med Univ Warsaw, Dept Clin Immunol, PL-02006 Warsaw, Poland

[6] DRK Krankenhaus Rabenstein, Dept Dermatol, D-09117 Chemnitz, Germany

来源：

SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期

关键词：

Atopic dermatitis; Biomarker; Diet; Gut-skin axis; Leaky gut; Metabolite; Microbiome; SKIN; MICROBIOTA; DISEASE; MICE;

D O I：

10.1038/s41598-025-09520-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dysbiosis of the gut microbiota may contribute to metabolic dysregulation, intestinal barrier disruption, and inflammatory disorders. The objective was to identify gut-derived metabolites and leaky gut biomarkers linked to atopic dermatitis. Fifty adult patients with atopic dermatitis and 25 controls were studied. Blood levels of 30 biomarkers were analyzed using liquid chromatography-mass spectrometry, ELISA, and Luminex assays, and correlated with clinical outcomes (EASI, SCORAD, extent of skin lesions). We discovered higher concentrations of caproic acid, glycerophosphocholine, Reg3A, I-FABP, IL-10, and IL-22 in patients with atopic dermatitis compared to controls, while the concentration of trimethylamine was lower. Disease severity was associated with lower caproic acid and isocaproic acid levels. Indoxyl and leaky gut biomarkers (LBP, Reg3A, IL-10, IL-22) correlated with higher disease activity. Leaky gut-related biomarkers were positively associated with C6 short-chain fatty acids and negatively with indoxyl. These findings highlight potential biomarkers of the gut-skin axis that could aid in predicting the onset and evolution of atopic dermatitis. Given that short-chain fatty acids and indoxyl are fermentation products of fiber and protein, respectively, our results suggest that a fiber-rich diet and moderation of protein intake could be beneficial not only for metabolic health but also in managing atopic dermatitis.

引用

页数：10

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