Tegileridine in postoperative pain: a profile of its use

Tegileridine ((sic)(sic)(sic)) is a novel postoperative analgesic option indicated for moderate-to-severe postoperative pain in China. Tegileridine is a biased mu -opioid receptor agonist with minimal beta-arrestin-2 activation relative to morphine and may therefore provide effective analgesia with a lower risk of opioid-related adverse effects such as respiratory depression and gastrointestinal dysfunction. In phase 3 trials, tegileridine significantly reduced pain intensity in adult patients with moderate-to-severe postoperative pain following abdominal or orthopaedic surgeries. Tegileridine was generally well tolerated, with nausea and vomiting being the most common adverse events.