Safety of daily low-dose aspirin use during pregnancy in low-income and middle-income countries

被引：10

作者：

Short, Vanessa L. ^{[1
]}

Hoffman, Matthew ^{[2
]}

Metgud, Mrityunjay ^{[3
]}

Kavi, Avinash ^{[3
]}

Goudar, Shivaprasad S. ^{[3
]}

Okitawutshu, Jean ^{[4
]}

Tshefu, Antoinette ^{[4
]}

Bose, Carl L. ^{[5
]}

Mwenechanya, Musaku ^{[6
]}

Chomba, Elwyn ^{[6
]}

Carlo, Waldemar A. ^{[7
]}

Figueroa, Lester ^{[8
]}

Garces, Ana ^{[8
]}

Krebs, Nancy F. ^{[9
]}

Jessani, Saleem ^{[10
]}

Saleem, Sarah ^{[10
]}

Goldenberg, Robert L. ^{[11
]}

Das, Prabir Kumar ^{[12
]}

Patel, Archana ^{[12
]}

Hibberd, Patricia L. ^{[13
]}

Achieng, Emmah ^{[14
]}

Nyongesa, Paul ^{[14
]}

Esamai, Fabian

Bucher, Sherri ^{[15
]}

Nowak, Kayla J. ^{[16
]}

Goco, Norman ^{[17
]}

Nolen, Tracy L. ^{[17
]}

Mcclure, Elizabeth M. ^{[17
]}

Koso-Thomas, Marion ^{[18
]}

Miodovnik, Menachem ^{[18
]}

Derman, Richard J. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Obstet & Gynecol, Philadelphia, PA 19107 USA

[2] Christiana Care, Dept Obstet & Gynecol, Newark, DE USA

[3] KLE Acad Higher Educ & Res, Jawaharlal Nehru Med Coll, Belagavi, Karnataka, India

[4] Univ Kinshasa, Kinshasa Sch Publ Hlth, Kinshasa, DEM REP CONGO

[5] Univ North Carolina, Chapel Hill, NC USA

[6] Univ Teaching Hosp, Lusaka, Zambia

[7] Univ Alabama Birmingham, Dept Obstet Gynecol, Birmingham, AL USA

[8] Inst Nutr Ctr Amer & Panama, Guatemala City, Guatemala

[9] Univ Colorado, Sch Med, Aurora, CO USA

[10] Aga Khan Univ, Karachi, Pakistan

[11] Columbia Univ, Dept Obstet Gynecol, New York, NY USA

[12] Lata Med Res Fdn, Nagpur, India

[13] Boston Univ, Sch Publ Hlth, Dept Global Hlth, Boston, MA USA

[14] Moi Univ, Sch Med, Dept Child Hlth & Paediat, Eldoret, Kenya

[15] Indiana Univ Sch Med, Indianapolis, IN USA

[16] Res Triangle Inst Int, Res Triangle Pk, NC USA

[17] Res Triangle Inst Int, Social Stat & Environm Hlth Sci, Res Triangle Pk, NC USA

[18] Eunice Kennedy Shriver Natl Inst Child Hlth & Huma, NIH, Bethesda, MD USA

来源：

AJOG GLOBAL REPORTS | 2021年 / 1卷 / 01期

关键词：

low-and middle-income countries; low-dose aspirin; potential side effects; pregnancy; preterm birth; safety; unexpected emergency medical visits; PRETERM BIRTH; MORTALITY; PREVENTION; WOMEN;

D O I：

10.1016/j.xagr.2021.100003

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

BACKGROUND: The daily use of low-dose aspirin may be a safe, widely available, and inexpensive intervention for reducing the risk of pre-term birth. Data on the potential side effects of low-dose aspirin use during pregnancy in low-and middle-income countries are needed. OBJECTIVE: This study aimed to assess differences in unexpected emergency medical visits and potential maternal side effects from a randomized, double-blind, multicountry, placebo-controlled trial of low-dose aspirin use (81 mg daily, from 6 to 36 weeks' gestation). STUDY DESIGN: This study was a secondary analysis of data from the Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas trial, a trial of the Global Network for Women's and Children's Health conducted in India (2 sites), Pakistan, Guatemala, Democratic Republic of the Congo, Kenya, and Zambia. The outcomes for this analysis were unexpected emergency medical visits and the occurrence of the following potential side effects-overall and separately-nausea, vomiting, rash or hives, diarrhea, gastritis, vaginal bleeding, allergic reaction, and any other potential side effects. Analyses were performed overall and by geographic region. RESULTS: Between the aspirin (n=5943) and placebo (n=5936) study groups, there was no statistically significant difference in the risk of unexpected emergency medical visits or the risk of any potential side effect (overall). Of the 8 potential side effects assessed, only 1 (rash or hives) presented a different risk by treatment group (4.2% in the aspirin group vs 3.5% in the placebo group; relative risk, 1.20; 95% confidence interval, 1.01-1.43; P=.042). CONCLUSION: The daily use of low-dose aspirin seems to be a safe intervention for reducing the risk of preterm birth and well tolerated by nulliparous pregnant women between 6 and 36 weeks' gestation in low-and middle-income countries.

引用

页数：9

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