Determination of Acid Dissociation Constants of Some 2-(3H) -Benzoxazolone Derivatives by UV-Vis Spectrophotometry

被引：0

作者：

Erkan, Semra Altunterim ^{[1
]}

Celik, Hayati ^{[2
]}

Kesanli, Banu ^{[3
]}

机构：

[1] Near East Univ, Fac Pharm, Dept Analyt Chem, Nicosia, North Cyprus, Cyprus

[2] Yeditepe Univ, Fac Pharm, Dept Analyt Chem, Istanbul, Turkiye

[3] Cyprus Int Univ, Fac Arts & Sci, Dept Basic Sci & Humanities, Nicosia, North Cyprus, Cyprus

来源：

IRANIAN JOURNAL OF CHEMISTRY & CHEMICAL ENGINEERING-INTERNATIONAL ENGLISH EDITION | 2025年 / 44卷 / 03期

关键词：

Benzoxazolone; NSAIDs; pKa; Dissociation constant; UV-Vis; spectrophotometry; PK(A) VALUES; DRUGS;

D O I：

10.30492/IJCCE.2025.2042480.6821

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The acid dissociation constant values of some 2-(3H)-benzoxazolone derivatives were determined in buffered solutions by using the UV-Vis spectrophotometric method. These compounds have benzoxazolone core structures with arylpiperazine substituents and have been investigated for their anti-inflammatory and analgesic activities. The 2-(3H)-benzoxazolone derivatives showed acid dissociation constant values ranging from 8.26 to 9.28. The 5-chloro-2-(3H)-benzoxazolone derivatives exhibit higher acidity than the 2-(3H)-benzoxazolone derivatives. Additionally, a comparison of 5-chloro-2-(3H)-benzoxazolone derivatives showed that derivatives with halogen-containing R2 groups exhibited higher acidity. The findings of this study also suggest that UV-Vis spectrophotometry is one of the most effective techniques for measuring acid dissociation constant values.

引用

页码：730 / 735

页数：6

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