Synthesis of pyrrolo[3,2-d]pyrimidine-2,4(3H)-diones bydomino C-N coupling/hydroamination reactions

被引：0

作者：

de Abreu, Ruben Manuel Figueira ^{[1
]}

Tiedemann, Robin ^{[1
]}

Ehlers, Peter ^{[1
]}

Langer, Peter ^{[1
,2
]}

机构：

[1] Univ Rostock, Inst Chem, Albert Einstein Str 3A, D-18059 Rostock, Germany

[2] Univ Rostock eV, Leibniz Inst Katalyse, Albert Einstein Str 29A, D-18059 Rostock, Germany

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 21卷

关键词：

alkynes; catalysis; cyclizations; domino reactions; heterocycles; BIOLOGICAL-ACTIVITY; INHIBITORS; GROWTH; DESIGN; PYRROLOPYRIMIDINES;

D O I：

10.3762/bjoc.21.82

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of pyrrolo[3,2-d]pyrimidine-2,4(3H)-diones were prepared by a combination of Sonogashira reaction and subsequentcyclization by domino C-N coupling/hydroamination reaction. The optical properties (UV-vis absorption and fluorescence) dependon the substitution pattern of the compounds.

引用

页码：1010 / 1017

页数：8

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