Synthesis and Biological Evaluation of Isoaurone Derivatives as Anti-Inflammatory Agents

被引：0

作者：

Yu, Fei ^{[1
]}

Liu, Zhe ^{[2
]}

Song, Yuan ^{[2
]}

Zhang, Jinfeng ^{[1
]}

Bi, Yongsheng ^{[1
]}

Jiang, Dianzhuo ^{[1
]}

机构：

[1] Jilin Engn Vocat Coll, Siping 136001, Jilin, Peoples R China

[2] Jilin Med Univ, Jilin 132013, Jilin, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2025年

关键词：

isoaurone analogs; anti-inflammatory; ear edema model; inhibition rates; ISOAUROSTATIN;

D O I：

10.1007/s10600-025-04728-w

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel class of isoaurone analogs was designed, synthesized, and investigated in vivo for their anti-inammatory activity using a xylene-induced ear edema model. Isoaurones 8a-e exhibited anti-inflammatory activity at a dose of 100 mg/kg with inhibition rates ranging from 21.75% to 34.46%. 3-(4-(3-((5-(3-Chlorophenyl)-4H-1,2,4-triazol-3-yl)thio)propoxy)benzylidene)-6-methoxybenzofuran-2(3H)-one (8e) showed the most potent growth inhibitory effects (34.46%), indicated by the slightly higher inhibitory effects of celecoxib (31.92%).

引用

页数：5

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