Case Report: Hepatic sarcoidosis-like reaction from neoadjuvant pembrolizumab in early-stage triple-negative breast cancer

被引：0

作者：

Tan, Yujing ^{[1
,2
,3
]}

Wang, Yu ^{[4
]}

Liu, Xiaoyan ^{[5
]}

Ma, Qin ^{[4
]}

Zeng, Cheng ^{[1
,2
,3
]}

Zhu, Aihua ^{[6
]}

Sun, Xiaoying ^{[6
]}

Ma, Fei ^{[1
,2
,3
]}

Wang, Jiani ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Med Oncol, Beijing, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Beijing, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Beijing, Peoples R China

[4] Chinese Acad Med Sci, Shanxi Prov Canc Hosp,Shanxi Hosp,Canc Hosp, Canc Hosp,Shanxi Med, Breast Radiotherapy Ward,Dept Radiotherapy, Beijing, Shanxi, Peoples R China

[5] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Resp & Crit Care Med, Beijing, Peoples R China

[6] Canc Hosp Huanxing Chaoyang Dist, Dept Med Oncol, Beijing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2025年 / 16卷

基金：

中国国家自然科学基金;

关键词：

triple-negative breast cancer; pembrolizumab; sarcoidosis-like reaction; neoadjuvant immunotherapy; early breast cancer;

D O I：

10.3389/fimmu.2025.1589191

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Drug-induced sarcoidosis-like reaction (DISR) is a rare adverse event associated with immunotherapy. Currently, there is no standardized treatment protocol for DISR linked to immune checkpoint inhibitors (ICIs). This study presents a case of an early-stage triple-negative breast cancer (TNBC) patient who developed hepatic sarcoidosis-like reactions during neoadjuvant pembrolizumab therapy. We provide an overview of ICI-induced sarcoidosis-like reactions in cancer patients, including incidence, mechanisms, clinical manifestations, treatment, and prognosis. Additionally, we discuss the significance of one-year adjuvant immunotherapy for early-stage TNBC patients who achieved pathological complete response after neoadjuvant therapy, offering insights for individualized therapeutic strategies in this population.

引用

页数：5

共 15 条

[1] Radiologic Manifestations of Immune-Related Adverse Events in Patients With Metastatic Melanoma Undergoing Anti-CTLA-4 Antibody Therapy [J].

Bronstein, Yulia ;

Ng, Chaan S. ;

Hwu, Patrick ;

Hwu, Wen-Jen .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2011, 197 (06) :W992-W1000

[2] Sarcoidosis-Like Reactions Induced by Checkpoint Inhibitors [J].

Gkiozos, Ioannis ;

Kopitopoulou, Alexandra ;

Kalkanis, Alexandros ;

Vamvakaris, Ioannis N. ;

Judson, Marc A. ;

Syrigos, Konstantinos N. .

JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (08) :1076-1082

[3]

Jayan Athira, 2024, JCO Oncol Pract, pOP2400371, DOI 10.1200/OP.24.00371

[4] Pulmonary sarcoidosis-like reactions induced by sintilimab in esophageal cancer: A case report [J].

Li, Haoqian ;

Mu, Fengchun ;

Zou, Bing ;

Wang, Linlin .

MEDICINE, 2023, 102 (31) :E34432

[5] Retrospective study of the incidence of sarcoidosis-like reaction in patients treated with immunotherapy [J].

Li, Y. ;

Flavell, R. R. ;

Juarez, R. ;

Chow, M. ;

Wu, C. ;

Tsai, K. ;

Daud, A. ;

Behr, S. C. .

CLINICAL RADIOLOGY, 2023, 78 (02) :E131-E136

[6] Renal Sarcoidosis-like Reaction Induced by PD-1 Inhibitor Treatment in Non-Small Cell Lung Cancer: A Case Report and Literature Review [J].

Park, Sang-Don ;

Kim, Mee-Seon ;

Han, Man-Hoon ;

Kim, Yong-Jin ;

Jung, Hee-Yeon ;

Choi, Ji-Young ;

Cho, Jang-Hee ;

Park, Sun-Hee ;

Kim, Chan-Duck ;

Kim, Yong-Lim ;

Lim, Jeong-Hoon .

MEDICINA-LITHUANIA, 2023, 59 (05)

[7] Sarcoidosis-like reactions in metastatic renal cell carcinoma patients treated with immune-based combinations [J].

Rizzo, Mimma ;

Pezzicoli, Gaetano ;

Ganini, Carlo ;

Carone, Luisa ;

Calio, Anna ;

Brunelli, Matteo ;

Cosmai, Laura ;

Porta, Camillo .

IMMUNOTHERAPY, 2024, 16 (09) :603-609

[8] Hilar/mediastinal and cutaneous drug-induced sarcoidosis-like reaction associated with immune checkpoint inhibitors in metastatic colorectal cancer: a case report [J].

Sagawa, Tamotsu ;

Sato, Yasushi ;

Nagashima, Hiroyuki ;

Takada, Kohichi ;

Takahashi, Mamoru ;

Hirakawa, Masahiro ;

Hamaguchi, Kyoko ;

Tamura, Fumito ;

Fujikawa, Koshi ;

Okamoto, Koichi ;

Kawano, Yutaka ;

Sogabe, Masahiro ;

Miyamoto, Hiroshi ;

Takayama, Tetsuji .

FRONTIERS IN IMMUNOLOGY, 2023, 14

[9] Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer [J].

Schmid, P. ;

Cortes, J. ;

Dent, R. ;

Pusztai, L. ;

McArthur, H. ;

Kummel, S. ;

Bergh, J. ;

Denkert, C. ;

Park, Y. H. ;

Hui, R. ;

Harbeck, N. ;

Takahashi, M. ;

Untch, M. ;

Fasching, P. A. ;

Cardoso, F. ;

Andersen, J. ;

Patt, D. ;

Danso, M. ;

Ferreira, M. ;

Mouret-Reynier, M-A ;

Im, S-A ;

Ahn, J-H ;

Gion, M. ;

Baron-Hay, S. ;

Boileau, J-F ;

Ding, Y. ;

Tryfonidis, K. ;

Aktan, G. ;

Karantza, V ;

O'Shaughnessy, J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (06) :556-567

[10] Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer [J].

Schmid, Peter ;

Cortes, Javier ;

Dent, Rebecca ;

McArthur, Heather ;

Pusztai, Lajos ;

Kuemmel, Sherko ;

Denkert, Carsten ;

Park, Yeon Hee ;

Hui, Rina ;

Harbeck, Nadia ;

Takahashi, Masato ;

Im, Seock-Ah ;

Untch, Michael ;

Fasching, Peter A. ;

Mouret-Reynier, Marie-Ange ;

Foukakis, Theodoros ;

Ferreira, Marta ;

Cardoso, Fatima ;

Zhou, Xuan ;

Karantza, Vassiliki ;

Tryfonidis, Konstantinos ;

Aktan, Gursel ;

O'Shaughnessy, Joyce .

NEW ENGLAND JOURNAL OF MEDICINE, 2024, 391 (21) :1981-1991

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