Effectiveness and patient-reported impact of on-flare retreatment in patients with rheumatoid arthritis: insights from retrospective long-term real-world data

被引：0

作者：

Bertrand, Delphine ^{[1
]}

De Meyst, Elias ^{[1
,2
]}

Doumen, Michael ^{[1
,2
]}

De Cock, Diederik ^{[3
]}

Joly, Johan ^{[2
]}

Neerinckx, Barbara ^{[1
,2
]}

Pazmino, Sofia ^{[1
,4
]}

Pype, Nele ^{[1
]}

Conings, Tom ^{[1
]}

Westhovens, Rene ^{[1
,2
]}

Verschueren, Patrick ^{[1
,2
]}

机构：

[1] Katholieke Univ Leuven, Skeletal Biol & Engn Res Ctr, Dept Dev & Regenerat, Herestr 49, B-3000 Leuven, Belgium

[2] UZ Leuven, Rheumatol, Leuven, Belgium

[3] Vrije Univ Brussel VUB, Fac Med & Pharm, Dept Publ Hlth, Biostat & Med Informat Res Grp, Brussels, Belgium

[4] Katholieke Univ Leuven, Dept Chron Dis & Metab, Clin & Expt Endocrinol, B-3000 Leuven, Belgium

来源：

BMC RHEUMATOLOGY | 2025年 / 9卷 / 01期

关键词：

Rituximab; bDMARD; Rheumatoid arthritis; Long-term effectiveness; INTERSTITIAL LUNG-DISEASE; RITUXIMAB THERAPY; ACTIVITY INDEX; ACTIVITY SCORE; EFFICACY; SAFETY; COHORT; ESR;

D O I：

10.1186/s41927-025-00530-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundRituximab is known as an efficacious drug for the treatment of Rheumatoid Arthritis (RA). The original administration schedule consisted of two infusions of 1000 mg with a 2-week interval. We aimed to explore the long-term effectiveness of rituximab in daily clinical practice in patients with RA.MethodsData of patients with RA treated with rituximab in a tertiary university hospital (2006-2019) were retrospectively collected from rituximab initiation until December 1st 2019 or rituximab discontinuation, whichever came first. Rituximab retreatment was based on a treat-to-target-approach guided by a 28-joint disease activity score (DAS28) >= 3.2, as dictated by national reimbursement criteria. Rituximab retention rate was investigated using a Kaplan-Meier survival curve.ResultsWe collected data of 104 patients (59% female, 94% RF/ACPA-seropositive). At rituximab initiation, patients had a mean +/- SD age of 58 +/- 12 years and median disease duration of 12 (IQR 5-17) years. Patients were followed for a median of 40 (IQR 14-80) months and received a median of 3 (IQR 2-6) rituximab cycles. In total, 9% (9/104) patients discontinued rituximab and 14% (15/104) were treated with a reduced dose. Inherent to the retreatment strategy, disease activity fluctuated with a DAS28-increase before every new rituximab administration. Similar fluctuations were noticed for patient and physician reported outcomes. Proportion of patients continuing rituximab after three years was 94% (95% CI 89% - 99%).ConclusionsAlthough rituximab can be considered as an efficacious drug for RA treatment in daily practice, fluctuations in disease activity were noticed related to the retreatment approach, accompanied by impaired patient's wellbeing.Trial registrationNot applicable.

引用

页数：15

共 34 条

[31] Ultra-low doses of rituximab for continued treatment of rheumatoid arthritis (REDO study): a randomised controlled non-inferiority trial [J].