Role of Desmoglein Autoantibody in the Diagnosis of Pemphigus Vulgaris: A Case Report

被引:0
作者
Setiawan, Diane Lukito [1 ,2 ]
Fitriah, Munawaroh [2 ]
Awalia [3 ]
机构
[1] Univ Airlangga, Dr Soetomo Hosp, Fac Med, Dept Clin Pathol,Clin Pathol Subspecializat Progra, Surabaya, Indonesia
[2] Univ Airlangga, Dr Soetomo Hosp, Fac Med, Dept Clin Pathol, Jl Kedung Sroko 82, Surabaya 60132, Indonesia
[3] Univ Airlangga, Dr Soetomo Hosp, Fac Med, Dept Internal Med, Jl Mayjen Prof Moestopo 47, Surabaya 60131, Indonesia
关键词
Pemphigus vulgaris; autoantibody; desmoglein; MECHANISM;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pemphigus vulgaris (PV) is a group of autoimmune diseases that cause abnormalities in the form of lesions or blisters on the skin and mucous membranes. It often presents diagnostic challenges due to its varied clinical manifestations. Accurate diagnosis and treatment are essential to reduce mortality in patients with PV. Traditional diagnostic methods, such as histopathology and direct immunofluorescence, may not always provide conclusive results, especially if the patient does not have an intact bulla. Our report emphasizes the role of desmoglein autoantibody testing using enzyme-linked immunosorbent assay to confirm the diagnosis, allowing for prompt and targeted therapeutic interventions.
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页码:246 / 250
页数:5
相关论文
共 16 条
[1]  
Abasq C, 2009, ARCH DERMATOL, V145, P529, DOI 10.1001/archdermatol.2009.9
[2]   Vitamin D Metabolism, Mechanism of Action, and Clinical Applications [J].
Bikle, Daniel D. .
CHEMISTRY & BIOLOGY, 2014, 21 (03) :319-329
[3]   Long-Term Remissions of Severe Pemphigus After Rituximab Therapy Are Associated with Prolonged Failure of Desmoglein B Cell Response [J].
Colliou, Natacha ;
Picard, Damien ;
Caillot, Frederique ;
Calbo, Sebastien ;
Le Corre, Stephanie ;
Lim, Annick ;
Lemercier, Brigitte ;
Le Mauff, Brigitte ;
Maho-Vaillant, Maud ;
Jacquot, Serge ;
Bedane, Christophe ;
Bernard, Philippe ;
Caux, Frederic ;
Prost, Catherine ;
Delaporte, Emmanuel ;
Doutre, Marie-Sylvie ;
Dreno, Brigitte ;
Franck, Nathalie ;
Ingen-Housz-Oro, Saskia ;
Chosidow, Olivier ;
Pauwels, Christine ;
Picard, Catherine ;
Roujeau, Jean-Claude ;
Sigal, Michele ;
Tancrede-Bohin, Emmanuelle ;
Templier, Isabelle ;
Eming, Ruediger ;
Hertl, Michael ;
D'Incan, Michel ;
Joly, Pascal ;
Musette, Philippe .
SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (175)
[4]   Pemphigus: Current and Future Therapeutic Strategies [J].
Didona, Dario ;
Maglie, Roberto ;
Eming, Rudiger ;
Hertl, Michael .
FRONTIERS IN IMMUNOLOGY, 2019, 10
[5]   Complement Activation in Autoimmune Bullous Dermatoses: A Comprehensive Review [J].
Edwards, Gareth ;
Diercks, Gilles F. H. ;
Seelen, Marc A. J. ;
Horvath, Barbara ;
van Doorn, Martijn B. A. ;
Damman, Jeffrey .
FRONTIERS IN IMMUNOLOGY, 2019, 10
[6]   Estimation of vitamin D levels in patients with pemphigus vulgaris [J].
El-Komy, M. H. M. ;
Samir, N. ;
Shaker, O. G. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2014, 28 (07) :859-863
[7]   A multicentre randomized trial of the treatment of patients with pemphigus vulgaris with infliximab and prednisone compared with prednisone alone [J].
Hall, R. P., III ;
Fairley, J. ;
Woodley, D. ;
Werth, V. P. ;
Hannah, D. ;
Streilein, R. D. ;
McKillip, J. ;
Okawa, J. ;
Rose, M. ;
Keyes-Elstein, L. L. ;
Pinckney, A. ;
Overington, A. ;
Wedgwood, J. ;
Ding, L. ;
Welch, B. .
BRITISH JOURNAL OF DERMATOLOGY, 2015, 172 (03) :760-768
[8]  
Kasperkiewicz M, 2017, NAT REV DIS PRIMERS, V3, DOI [10.1038/nrdp.2017.27, 10.1038/nrdp.2017.26]
[9]   Diagnosis and management of pemphigus: Recommendations of an international panel of experts [J].
Murrell, Dedee F. ;
Pena, Sandra ;
Joly, Pascal ;
Marinovic, Branka ;
Hashimoto, Takashi ;
Diaz, Luis A. ;
Sinha, Animesh A. ;
Payne, Aimee S. ;
Daneshpazhooh, Maryam ;
Eming, Ruediger ;
Jonkman, Marcel F. ;
Mimouni, Daniel ;
Borradori, Luca ;
Kim, Soo-Chan ;
Yamagami, Jun ;
Lehman, Julia S. ;
Saleh, Marwah Adly ;
Culton, Donna A. ;
Czernik, Annette ;
Zone, John J. ;
Fivenson, David ;
Ujiie, Hideyuki ;
Wozniak, Katarzyna ;
Akman-Karakas, Ayse ;
Bernard, Philippe ;
Korman, Neil J. ;
Caux, Frederic ;
Drenovska, Kossara ;
Prost-Squarcioni, Catherine ;
Vassileva, Snejina ;
Feldman, Ron J. ;
Cardones, Adela Rambi ;
Bauer, Johann ;
Ioannides, Dimitrios ;
Jedlickova, Hana ;
Palisson, Francis ;
Patsatsi, Aikaterini ;
Uzun, Soner ;
Yayli, Savas ;
Zillikens, Detlef ;
Amagai, Masayuki ;
Hertl, Michael ;
Schmidt, Enno ;
Aoki, Valeria ;
Grando, Sergei A. ;
Shimizu, Hiroshi ;
Baum, Sharon ;
Cianchini, Guiseppe ;
Feliciani, Claudio ;
Iranzo, Pilar .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2020, 82 (03) :575-+
[10]  
Payne AS, 2019, Fitzpatrick's dermatology, V9th, P909