Tumor-Associated Macrophage in Breast Tumor Microenvironment

被引：0
作者：
Ma, Lingyao [1 ,2 ]
Jin, Yuexinzi [1 ,2 ]
Xu, Jian [1 ,2 ]
Zhang, Jiexin [1 ,2 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Lab Med, Nanjing 210029, Peoples R China
[2] Branch Natl Clin Res Ctr Lab Med, Nanjing 210029, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 13期
基金：
中国国家自然科学基金;
关键词：
breast cancer; tumor microenvironment; tumor-associated macrophage; nanodrug delivery system; MYELOID CELLS; TGF-BETA; CANCER; EXPRESSION; HYPOXIA; POLARIZATION; METASTASIS; ANGIOGENESIS; MONOCYTES; ADIPONECTIN;
D O I：
10.3390/ijms26135973
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Breast cancer (BC) is the most common cancer in women worldwide. It is one of the main causes of cancer-related mortality. The breast tumor microenvironment (Br-TME) has emerged as an important factor related to BC development and prognosis. Tumor-associated macrophages (TAMs) are the main effector cells in the Br-TME; they play key roles in regulating angiogenesis, immunosuppression, metastasis, and chemoresistance in BC patients. In this review, we introduce the macrophage niche in the Br-TME, particularly emphasizing the origin of TAMs. Next, we summarize the typical pathways and molecular mechanisms of the interactions between TAMs and various other components in the Br-TME. Finally, we provide an overview of drugs that target TAMs and discuss the prevailing technologies for drug delivery in the context of BC treatment. Identification of the dynamic variations in tumor-promoting TAMs will help reveal the key links that drive BC progression. This review provides a theoretical basis for upcoming clinical trials that may substantially benefit patients.
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页数：26
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