Exploring the pathogenesis of extranodal natural killer/T cell lymphoma complicated With EBV via microarray data analysis

被引：0

作者：

Peng, Yin-yin ^{[1
]}

Tang, Xiao-qiong ^{[1
]}

Wang, Xin ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Hematol Med, Chongqing 400016, Peoples R China

来源：

LEUKEMIA RESEARCH | 2025年 / 156卷

关键词：

Extranodal NK/T-cell lymphoma; Epstein-barr virus; Differentially expression; Gene ontology; KEGG pathway; Hub gene; T-CELL; AURORA-B; PHOSPHORYLATION; CDC20; PROLIFERATION; EXPRESSION; COMPLEX; PROTEIN; MYC;

D O I：

10.1016/j.leukres.2025.107909

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: To identify the common genes playing roles in the development of both the Extranodal Natural Killer/ T-cell lymphoma (ENKL) and Epstein-Barr virus (EBV), and to analyze their enrichment, protein-protein interaction (PPI) nework, and their hub genes. Methods: We analyzed the differential expressed genes (DEGs) of data sets GSE85599 and GSE169644 from the Gene Expression Omnibus (GEO) database using its GEO2R tool, analyzed the PPI network of DEGs using STRING database, analyzed the hub genes using Cytoscape software, and analyzed the enrichment of DEGs using DAVID database. Results: We identified 152 DEGs, and 14 hub genes among them, including TOP2A, AURKB, CDC20, MCM4, CCNB1, TYMS, FEN1, RRM2, CCNA2, MCM3, KIF11, BUB1, MCM6 and CDC6. PPI network and enrichment analysis show that DEGs are highly relavant with the process related with nucleus. Conclusions: In this study we identified the common DEGs of ENKL and EBV infections, found 14 hub DEGs that may mediate between them. Hope this study could provide new insights for further study of the molecular mechanism between EBV infection and ENKL.

引用

页数：8

共 49 条

[11] Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas [J].

Kataoka, Keisuke ;

Miyoshi, Hiroaki ;

Sakata, Seiji ;

Dobashi, Akito ;

Couronne, Lucile ;

Kogure, Yasunori ;

Sato, Yasuharu ;

Nishida, Kenji ;

Gion, Yuka ;

Shiraishi, Yuichi ;

Tanaka, Hiroko ;

Chiba, Kenichi ;

Watatani, Yosaku ;

Kakiuchi, Nobuyuki ;

Shiozawa, Yusuke ;

Yoshizato, Tetsuichi ;

Yoshida, Kenichi ;

Makishima, Hideki ;

Sanada, Masashi ;

Onozawa, Masahiro ;

Teshima, Takanori ;

Yoshiki, Yumiko ;

Ishida, Tadao ;

Suzuki, Kenshi ;

Shimada, Kazuyuki ;

Tomita, Akihiro ;

Kato, Motohiro ;

Ota, Yasunori ;

Izutsu, Koji ;

Demachi-Okamura, Ayako ;

Akatsuka, Yoshiki ;

Miyano, Satoru ;

Yoshino, Tadashi ;

Gaulard, Philippe ;

Hermine, Olivier ;

Takeuchi, Kengo ;

Ohshima, Koichi ;

Ogawa, Seishi .

LEUKEMIA, 2019, 33 (07) :1687-1699

[12] CDC20, a potential cancer therapeutic target, is negatively regulated by p53 [J].

Kidokoro, T. ;

Tanikawa, C. ;

Furukawa, Y. ;

Katagiri, T. ;

Nakamura, Y. ;

Matsuda, K. .

ONCOGENE, 2008, 27 (11) :1562-1571

[13] Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer [J].

Kikuchi, Junko ;

Kinoshita, Ichiro ;

Shimizu, Yasushi ;

Kikuchi, Eiki ;

Takeda, Kayoko ;

Aburatani, Hiroyuki ;

Oizumi, Satoshi ;

Konishi, Jun ;

Kaga, Kichizo ;

Matsuno, Yoshihiro ;

Birrer, Michael J. ;

Nishimura, Masaharu ;

Dosaka-Akita, Hirotoshi .

LUNG CANCER, 2011, 72 (02) :229-237

[14] A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis [J].

Kim, Seok Jin ;

Yoon, Dok Hyun ;

Jaccard, Arnaud ;

Chng, Wee Joo ;

Lim, Soon Thye ;

Hong, Huangming ;

Park, Yong ;

Chang, Kian Meng ;

Maeda, Yoshinobu ;

Ishida, Fumihiro ;

Shin, Dong-Yeop ;

Kim, Jin Seok ;

Jeong, Seong Hyun ;

Yang, Deok-Hwan ;

Jo, Jae-Cheol ;

Lee, Gyeong-Won ;

Choi, Chul Won ;

Lee, Won-Sik ;

Chen, Tsai-Yun ;

Kim, Kiyeun ;

Jung, Sin-Ho ;

Murayama, Tohru ;

Oki, Yasuhiro ;

Advani, Ranjana ;

d'Amore, Francesco ;

Schmitz, Norbert ;

Suh, Cheolwon ;

Suzuki, Ritsuro ;

Kwong, Yok Lam ;

Lin, Tong-Yu ;

Kim, Won Seog .

LANCET ONCOLOGY, 2016, 17 (03) :389-400

[15] EBV in T-/NK-Cell Tumorigenesis [J].

Kimura, Hiroshi .

HUMAN HERPESVIRUSES, 2018, 1045 :459-475

[16] Regulatory Role of Ribonucleotide Reductase Subunit M2 in Hepatocyte Growth and Pathogenesis of Hepatitis C Virus [J].

Kitab, Bouchra ;

Tsukiyama-Kohara, Kyoko .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (03)

[17] Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization [J].

Kumar, Raj ;

Rao, Gadiparthi N. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2022, 42 (04) :407-427

[18] Mutations of the p53 gene in nasal NK/T-cell lymphoma [J].

Li, T ;

Hongyo, T ;

Syaifudin, M ;

Nomura, T ;

Dong, ZM ;

Shingu, N ;

Kojya, S ;

Nakatsuka, S ;

Aozasa, K .

LABORATORY INVESTIGATION, 2000, 80 (04) :493-499

[19] Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study [J].

Li, Zheng ;

Xia, Yi ;

Feng, Li-Na ;

Chen, Jie-Rong ;

Li, Hong-Min ;

Cui, Jing ;

Cai, Qing-Qing ;

Sim, Kar Seng ;

Nairismagi, Maarja-Liisa ;

Laurensia, Yurike ;

Meah, Wee Yang ;

Liu, Wen-Sheng ;

Guo, Yun-Miao ;

Chen, Li-Zhen ;

Feng, Qi-Sheng ;

Pang, Chi Pui ;

Chen, Li Jia ;

Chew, Soo Hong ;

Ebstein, Richard P. ;

Foo, Jia Nee ;

Liu, Jianjun ;

Ha, Jeslin ;

Khoo, Lay Poh ;

Chin, Suk Teng ;

Zeng, Yi-Xin ;

Aung, Tin ;

Chowbay, Balram ;

Diong, Colin Phipps ;

Zhang, Fen ;

Liu, Yan-Hui ;

Tang, Tiffany ;

Tao, Miriam ;

Quek, Richard ;

Mohamad, Farid ;

Tan, Soo Yong ;

Teh, Bin Tean ;

Ng, Siok Bian ;

Chng, Wee Joo ;

Ong, Choon Kiat ;

Okada, Yukinori ;

Raychaudhuri, Soumya ;

Lim, Soon Thye ;

Tan, Wen ;

Peng, Rou-Jun ;

Khor, Chiea Chuen ;

Bei, Jin-Xin .

LANCET ONCOLOGY, 2016, 17 (09) :1240-1247

[20] Genome-Wide Analysis of Epstein-Barr Virus Isolated from Extranodal NK/T-Cell Lymphoma, Nasal Type [J].

Lin, Ningjing ;

Ku, Wenjing ;

Song, Yuqin ;

Zhu, Jun ;

Lu, Zheming .

ONCOLOGIST, 2019, 24 (09) :E905-E913

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