Simultaneous determination of benzo[a]pyrene and NNK in mainstream cigarette smoke by gas chromatography-tandem mass spectrometry

被引：0

作者：

Chen, Xiaoshui ^{[1
]}

Tang, Xiaodong ^{[1
]}

Zhang, Bo ^{[1
]}

Jiang, Jialei ^{[1
]}

Zhu, Shuxiu ^{[1
]}

Lu, Minghua ^{[1
]}

机构：

[1] Technology Center of China Tobacco Zhejiang Industrial Co., Ltd., Hangzhou, China

来源：

Tobacco Science and Technology | 2015年 / 48卷 / 09期

关键词：

Ketones - Barium compounds - Gas chromatography - Phase separation - Smoke - Tobacco - Flow of gases - Pyrene;

D O I：

10.16135/j.issn1002-0861.20150909

中图分类号：

学科分类号：

摘要：

A method for simultaneously determining the benzo[a]pyrene (BaP) and 4-(N-methyl-Nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mainstream cigarette smoke by gas chromatography-tandem mass spectrometry (GC-MS/MS) was developed. The total particulate matter of mainstream cigarette smoke was collected on a Cambridge filter pad, then extracted with toluene by oscillation. The extract was cleaned up by dispersive solid phase extraction (d-SPE), concentrated by nitrogen gas flow, separated by DB-35MS column, and determined by internal standard method under multi-reaction monitoring (MRM) mode. The results showed that: 1) The limits of quantitations (LOQs), recoveries and relative standard deviations (RSDs) of NNK and BaP were 0.36 and 0.29 ng/cig, 78.8%-95.5% and 101.6%-106.6%, 2.3%-15.4% and 2.9%-14.4%, respectively. 2) Comparing with the standard method, the developed method was simpler in pretreatment, and capable of simultaneous determination of the two target analytes. 3) The data of 27 cigarette samples determined by the developed method well agreed with those by the standard method, there was no significant difference. The method is simple, accurate and suitable for the simultaneous determination of NNK and BaP in mainstream cigarette smoke. © 2015, Editorial Office of Tobacco Science and Technology. All right reserved.

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