Numerical drugs for calcium-induced calcium release

被引：0

作者：

Tveito, Aslak ^{[1
]}

Lines, Glenn T. ^{[1
]}

机构：

[1] Center for Biomedical Computing, Simula Research Laboratory, Lysaker, Norway

来源：

Lecture Notes in Computational Science and Engineering | 2016年 / 111卷

关键词：

Stochastic models - Stochastic systems - Controlled drug delivery - Probability density function - Targeted drug delivery;

D O I：

10.1007/978-3-319-30030-6_9

中图分类号：

学科分类号：

摘要：

In the previous chapter, we developed models of calcium-induced calcium release (CICR) in terms of both a stochastic release model and a model of the probability density functions of the states involved in the stochastic release model. The models incorporated the effects of mutations in both the ryanodine receptors (RyRs) and the L-type calcium channels (LCCs). The purpose of the present chapter is to introduce theoretical drugs aimed at repairing the effect of mutations of both the LCCs and RyR channels. Model parameters used throughout this chapter are given in Table 9.1. © The Author(s) 2016.

引用

页码：143 / 152