Spirulina supplementation and its effects on inflammation and oxidative stress: A systematic review and Meta-analysis on randomized clinical trials

被引：0

作者：

Mousavi, Samin ^{[1
]}

Yegdaneh, Afsaneh ^{[1
,4
]}

Shirani, Mahsa ^{[2
]}

Feizi, Awat ^{[3
]}

Ghanadian, Mustafa ^{[1
,4
]}

机构：

[1] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Pharmacognosy, Esfahan, Iran

[2] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran

[3] Isfahan Univ Med Sci, Dept Biostat & Epidemiol, Esfahan, Iran

[4] Isfahan Univ Med Sci, Isfahan Pharmaceut Sci Res Ctr, Sch Pharm & Pharmaceut Sci, Dept Phytochem, Esfahan, Iran

来源：

JOURNAL OF FUNCTIONAL FOODS | 2025年 / 131卷

关键词：

Spirulina; Oxidative stress; Inflammation; Systematic review; meta-analysis; GRADE analysis; C-PHYCOCYANIN; DOUBLE-BLIND; ANTIINFLAMMATORY ACTIVITY; HEALTH-BENEFITS; MUSCLE DAMAGE; ANTIOXIDANT; PLATENSIS; EXPRESSION; DISEASE; CAROTENOIDS;

D O I：

10.1016/j.jff.2025.106945

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The study aimed to assess the effects of Spirulina as a supplementary treatment for inflammatory conditions amidst ongoing debates regarding its benefits for healthy individuals and patients. This systematic review and meta-analysis included 22 studies with 5385 participants, utilizing databases such as Scopus, Google Scholar, PubMed-Medline, and Web of Science, covering the period from 1995 to August 2024. The meta-analysis demonstrated that Spirulina supplementation significantly reduced inflammatory biomarkers, including CRP levels (SMD: -0.972 mg/dl), interleukin-6 (SMD: -0.532), and TNF-alpha (SMD: -0.579 mg/dl). Furthermore, oxidative stress biomarkers showed a significant decrease in malondialdehyde (SMD: -0.929) and an increase in total antioxidant capacity (SMD: 1.086). The findings strongly advocate for Spirulina as a valuable dietary supplement for both healthy individuals and patients, aiming to lower inflammatory markers and enhance antioxidant capacity.

引用

页数：15

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