Resonant electron capture by aspartame and aspartic acid molecules

被引：7

作者：

Muftakhov M.V. ^{[1
]}

Shchukin P.V. ^{[1
]}

机构：

[1] Institute of Molecule and Crystal Physics, Ufa Research Centre of Russian Academy of Sciences, Prospect Octyabrya 151, Ufa

来源：

Rapid Communications in Mass Spectrometry | 2016年 / 30卷 / 24期

关键词：

Amino acids - Chains - Copyrights - Electrons - Mass spectrometry - Molecules - Negative ions - Photodissociation - Quantum chemistry;

D O I：

10.1002/rcm.7738

中图分类号：

学科分类号：

摘要：

Rationale: The processes for dissociative electron capture are the key mechanisms for decomposition of biomolecules, proteins in particular, under interaction with low-energy electrons. Molecules of aspartic acid and aspartame, i.e. modified dipeptides, were studied herein to define the impact of the side functional groups on peptide chain decomposition in resonant electron-molecular reactions. Methods: The processes of formation and decomposition of negative ions of both aspartame and aspartic acid were studied by mass spectrometry of negative ions under resonant electron capture. The obtained mass spectra were interpreted under thermochemical analysis by quantum chemical calculations. Results: Main channels of negative molecular ions fragmentation were found and characteristic fragment ions were identified. Conclusions: The СООН fragment of the side chain in aspartic acid is shown to play a key role like the carboxyl group in amino acids and aliphatic oligopeptides. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

引用

页码：2577 / 2584

页数：7

共 12 条

[1]

Muftakhov M.V., Shchukin P.V., Resonant dissociative electron capture by the simplest amino acids and dipeptides, Russ. Chem. Bull., Int. Ed., 50, (2010)

[2]

Muftakhov M.V., Shchukin P.V., Dissociative electron attachment to glycyl-glycine, glycyl-alanine and alanyl-alanine, Phys. Chem. Chem. Phys., 13, (2011)

[3]

Muftakhov M.V., Shchukin P.V., Resonant dissociative electron capture by simple tripeptides, Russ. Chem. Bull., Int. Ed., 63, (2015)

[4]

Vasil'ev Y.V., Figard B.J., Voinov V.G., Barofsky D.F., Deinzer M.L., Resonant electron capture by some amino acids and their methyl esters, J. Am. Chem. Soc., 128, (2006)

[5]

Khatymov R.V., Muftakhov M.V., Mazunov V.A., Phenol, chlorobenzene and chlorophenol isomers: resonant states and dissociative electron attachment, Rapid Commun. Mass Spectrom., 17, (2003)

[6]

Muftakhov M.V., Vasil'ev Y.V., Mazunov V.A., Determination of electron affinity of carbonyl radicals by means of negative ion mass-spectrometry, Rapid Commun. Mass Spectrom., 13, (1999)

[7]

Wu J., Xu X., The X1 method for accurate and efficient prediction of heats of formation, J. Chem. Phys., 127, (2007)

[8]

Abdoul-Carime H., Gohlke S., Illenberger E., Fragmentation of tryptophan by low-energ y electrons, Chem. Phys. Lett., 402, (2005)

[9]

Shchukin P.V., Muftakhov M.V., Morre J., Deinzer M.L., Vasil'ev Y.V., High resolution mass analysis of N- and C-terminal negative ions resulting from resonance electron capture by aliphatic amino acids, J. Chem. Phys., 132, (2010)

[10]

Thornburn R., Ionization and dissociation by electron impact in carbon tetrabromide, Brit. J. Appl. Phys., 16, (1965)

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