Assessing Metabolic Syndrome Risk in Children and Adolescents with Prader-Willi Syndrome: A Comparison of Index Performance

被引：0

作者：

Grugni, Graziano ^{[1
]}

Lupi, Fiorenzo ^{[2
]}

Bonetti, Mirko ^{[3
]}

Bocchini, Sarah ^{[4
]}

Bucolo, Carmen ^{[5
]}

Corica, Domenico ^{[6
]}

Crino, Antonino ^{[7
]}

Faienza, Maria Felicia ^{[8
]}

Fintini, Danilo ^{[4
]}

Licenziati, Maria Rosaria ^{[9
]}

Maghnie, Mohamad ^{[10
,11
]}

Mozzillo, Enza ^{[12
]}

Pajno, Roberta ^{[5
]}

Zampino, Giuseppe ^{[7
]}

Sartorio, Alessandro ^{[1
]}

Radetti, Giorgio ^{[13
]}

机构：

[1] Ist Ricovero & Cura Carattere Sci IRCCS, Ist Auxol Italiano, Expt Lab Auxoendocrinol Res, I-28824 Piancavallo Verbania, Verbania, Italy

[2] Paracelsus Med Univ PMU, Hosp Bolzano SABES ASDAA, Div Neonatol NICU, Teaching Hosp, I-39100 Bolzano, Italy

[3] Observ Hlth Hlth, Dept Prov Bolzano, I-39100 Bolzano, Italy

[4] IRCCS, Bambino Gesu Children Hosp, Prader Willi Reference Ctr, Endocrinol & Diabetol Unit, I-00165 Rome, Italy

[5] IRCCS, San Raffaele Inst, Pediat Unit, I-20132 Milan, Italy

[6] Univ Messina, Dept Human Pathol Adulthood & Childhood G Barresi, Pediat Unit, I-98124 Messina, Italy

[7] IRCCS, Fdn Policlin Univ A Gemelli, Rare Dis Unit, I-00136 Rome, Italy

[8] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Pediat Unit, I-70124 Bari, Italy

[9] Santobono Pausilipon Childrens Hosp, Dept Neurosci, Neuroendocrine Dis & Obes Unit, I-80139 Naples, Italy

[10] IRCCS, Ist Giannina Gaslini, Dept Pediat, I-16147 Genoa, Italy

[11] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, I-16147 Genoa, Italy

[12] Federico II Univ Naples, Dept Translat Med Sci, Sect Pediat, I-80131 Naples, Italy

[13] Marienklin, I-39100 Bolzano, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2025年 / 14卷 / 13期

关键词：

Prader-Willi syndrome; metabolic syndrome; Triglycerides/HDL-Cholesterol ratio; BODY-MASS INDEX; WAIST CIRCUMFERENCE; CHOLESTEROL RATIO; EUROPEAN CHILDREN; REFERENCE VALUES; YOUNG-CHILDREN; BLOOD-LIPIDS; ADIPOSITY; MORTALITY; HEIGHT;

D O I：

10.3390/jcm14134716

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Currently, there is a lack of data regarding the reliability of different anthropometric, instrumental, and biochemical indexes in detecting metabolic syndrome (MetS) in pediatric patients with Prader-Willi syndrome (PWS). Therefore, this study aimed to compare the accuracy of different indices to identify the simplest and most accurate predictor of MetS in this at-risk population. Methods: We conducted a multicenter study involving 124 children and adolescents with PWS (61 males and 63 females), aged 13.6 +/- 3.7 years. For each participant, we assessed all components of MetS, defined according to either the Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS (IDEFICS) study or the International Diabetes Federation (IDF) criteria, based on age. The following indexes were calculated: Body Mass Index (BMI), BMI standard deviation score (BMI-SDS), tri-ponderal mass index, body mass fat index, fat mass index, fat-free mass index, body shape index, visceral adiposity index, waist-to-height ratio, cardiometabolic index, total cholesterol/high-density lipoprotein cholesterol (HDL-C) ratio, and triglycerides/HDL-C (TG/HDL-C) ratio. Results: MetS was identified in 24 subjects (9 females and 15 males), representing 19.4% of the sample. When comparing the receiver operating characteristic (ROC) curves, the TG/HDL-C ratio and cardiometabolic index demonstrated significantly better performance than the other indices in detecting MetS, with no difference between the two. As a result, we focused on the TG/HDL-C ratio since it is the simplest measure, requiring no additional anthropometric data compared to the cardiometabolic index. Additionally, applying age- and gender-specific thresholds can further improve its accuracy. Conclusions: The TG/HDL-C ratio, which requires only two standard biochemical markers, provides the same accuracy as more complex indexes in detecting MetS in children and adolescents with PWS, making it the optimal predictor for MetS in this population.

引用

页数：19

共 52 条

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