Plant-based dietary patterns and breast cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study

被引：0

作者：

Shah, Sanam ^{[1
]}

Laouali, Nasser ^{[2
]}

Mahamat-Saleh, Yahya ^{[1
]}

Biessy, Carine ^{[1
]}

Nicolas, Genevieve ^{[1
]}

Rinaldi, Sabina ^{[1
]}

Zamora-Ros, Raul ^{[3
]}

Papadimitriou, Nikos ^{[1
]}

Morales-Berstein, Fernanda ^{[4
,5
]}

Dahm, Christina C. ^{[6
]}

Christensen, Anne Kristine Lundgard ^{[6
]}

Mellemkjaer, Lene ^{[7
]}

Nielsen, Anne Marie Overgaard ^{[7
]}

Mancini, Francesca Romana ^{[8
]}

Ren, Xuan ^{[8
]}

Marques, Chloe ^{[8
]}

Katzke, Verena ^{[9
]}

Le Cornet, Charlotte ^{[9
]}

El-Khoury, Christine ^{[10
]}

Schulze, Matthias B. ^{[10
,11
]}

Agnoli, Claudia ^{[12
]}

Simeon, Vittorio ^{[13
]}

Tumino, Rosario ^{[14
]}

Milani, Lorenzo ^{[15
]}

Castro-Espin, Carlota ^{[1
,3
]}

Sanchez, Maria-Jose ^{[16
,17
,18
]}

Aizpurua, Amaia ^{[19
,20
]}

Colorado-Yohar, Sandra M. ^{[18
,21
,22
]}

Guevara, Marcela ^{[18
,23
,24
]}

Heath, Alicia ^{[25
]}

Aune, Dagfinn ^{[25
,26
,27
]}

Freisling, Heinz ^{[1
]}

Huybrechts, Inge ^{[1
]}

Dossus, Laure ^{[1
]}

机构：

[1] WHO, Nutr & Metab Branch, Int Agcy Res Canc, IARC WHO, 25 Ave Tony Garnier, F-69366 Lyon 07, France

[2] Mohammed VI Polytech Univ, Inst Biol Sci ISSB, Fac Med Sci UM6P, Ben Guerir, Morocco

[3] Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol ICO, Unit Nutr & Canc, Canc Epidemiol Res Programme, Barcelona, Spain

[4] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, England

[5] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, England

[6] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark

[7] Danish Canc Inst, Diet Canc & Hlth, Strandblvd 49, DK-2100 Copenhagen, Denmark

[8] Paris Saclay Univ, UVSQ, INSERM, Gustave Roussy,CESP, Villejuif, France

[9] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[10] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[11] Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany

[12] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Via Venezian 1, I-20133 Milan, Italy

[13] Univ Naples L Vanvitelli, Med Stat Unit, Naples, Italy

[14] Hyblean Assoc Epidemiol Res, AIRE ONLUS, Ragusa, Italy

[15] Univ Turin, Ctr Biostat Epidemiol & Publ Hlth, Dept Clin & Biol Sci, Orbassano, Turin, Italy

[16] Escuela Andaluza Salud Publ EASP, Granada 18011, Spain

[17] Inst Invest Biosanitaria ibs GRANADA, Granada 18012, Spain

[18] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBER, Madrid 28029, Spain

[19] Minist Hlth Basque Govt, Sub Directorate Publ Hlth & Addict Gipuzkoa, San Sebastian, Spain

[20] Biogipuzkoa Hlth Res Inst, Epidemiol Chron & Communicable Dis Grp, San Sebastian, Spain

[21] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[22] Univ Antioquia, Natl Fac Publ Hlth, Res Grp Demog & Hlth, Medellin, Colombia

[23] Inst Salud Publ & Laboral Navarra, Pamplona 31003, Spain

[24] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain

[25] Imperial Coll London, Sch Publ Hlth, Canc Epidemiol & Prevent Res Unit, London, England

[26] Norwegian Inst Publ Hlth, Canc Registry Norway, Dept Res, Oslo, Norway

[27] Oslo New Univ Coll, Dept Nutr, Oslo, Norway

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2025年

关键词：

Breast cancer; Dietary pattern; Plant-based diet; Prospective study; Mediation; Body mass index; MEDIATION; HEALTHFUL; WOMEN; VALIDITY; FIBER;

D O I：

10.1007/s10654-025-01277-y

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

While previous literature suggests that plant-based diets may be associated with a lower risk of breast cancer, evidence remains inconsistent. In this study, we investigated the association between adherence to plant-based diets and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Overall plant-based diet index (PDI), healthful (hPDI), and unhealthful PDI (uPDI) were calculated, and multivariable Cox models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of breast cancer for the three indices. Mediation analysis was performed to assess the role of body mass index (BMI) and waist circumference (WC) in the association between hPDI and postmenopausal breast cancer risk. Over a median follow-up of 14.9 years, 10,805 incident invasive breast cancer cases were identified among 258,343 women. In the multivariable model, not adjusted for BMI, higher adherence to hPDI was inversely associated with breast cancer risk, with HR per 1-SD increase [95% (CI)] of 0.97 (0.94, 0.99). The corresponding HRs (95% CI) per 1-SD increase for overall PDI and uPDI were 0.98 (0.96, 1.00) and 1.01 (0.99, 1.03), respectively. The associations between hPDI and postmenopausal breast cancer were partly explained by BMI and WC, which mediated 30% and 52% of this association, respectively. Higher adherence to hPDI was associated with a slightly lower total breast cancer risk. For postmenopausal breast cancer, this association was partly explained by lower BMI or WC. These findings suggest that promoting healthful plant-based diets could support breast cancer risk reduction.

引用

页数：12

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