A systematic review on the impact of micro-nanoplastics on human health: Potential modulation of epigenetic mechanisms and identification of biomarkers

被引：4
作者：
Subramanian, Darshini [1 ]
Ponnusamy Manogaran, Gopinath [1 ]
Dharmadurai, Dhanasekaran [2 ]
机构：
[1] Department of Biotechnology, School of Applied Sciences, REVA University, Karnataka, Bengaluru
[2] Department of Microbiology, Bharathidasan University, Tamil Nadu, Tiruchirappalli
来源：
Chemosphere | 2024年 / 363卷
关键词：
C; elegans; Epigenetic alterations; Exposure routes; Human homologous genes; Micro-nanoplastics; miRNA pathways;
D O I：
10.1016/j.chemosphere.2024.142986
中图分类号：
学科分类号：
摘要：
Epigenetic-mediated modifications, induced by adverse environmental conditions, significantly alter an organism's physiological mechanisms. Even after elimination of the stimulus, these epigenetic modifications can be inherited through mitosis, thereby triggering transgenerational epigenetics. Plastics, with their versatile properties, are indispensable in various aspects of daily life. However, due to mismanagement, plastics have become so ubiquitous in the environment that no ecosystem on Earth is free from micro-nanoplastics (MNPs). This situation has raised profound concerns regarding their potential impact on human health. Recently, both in vivo animal and in vitro human cellular models have shown the potential to identify the harmful effects of MNPs at the genome level. The emerging epigenetic impact of MNP exposure is characterized by short-term alterations in chromatin remodelling and miRNA modulation. However, to understand long-term epigenetic changes and potential transgenerational effects, substantial and more environmentally realistic exposure studies are needed. In the current review, the intricate epigenetic responses, including the NHL-2-EKL-1, NDK-1-KSR1/2, and WRT-3-ASP-2 cascades, wnt-signalling, and TGF- β signalling, established in model organisms such as C. elegans, mice, and human cell lines upon exposure to MNPs, were systematically examined. This comprehensive analysis aimed to predict human pathways by identifying human homologs using databases and algorithms. We are confident that various parallel miRNA pathways, specifically the KSR-ERK-MAPK pathway, FOXO-Insulin cascade, and GPX3-HIF-α in humans, may be influenced by MNP exposure. This influence may lead to disruptions in key metabolic and immune pathways, including glucose balance, apoptosis, cell proliferation, and angiogenesis. Therefore, we believe that these genes and pathways could serve as potential biomarkers for future studies. Additionally, this review emphasizes the origin, dispersion, and distribution of plastics, providing valuable insights into the complex relationship between plastics and human health while elaborating on the epigenetic impacts. © 2024 Elsevier Ltd
引用
收藏
相关论文
共 141 条
[1]  
AlMaadeed M.A.A., Ponnamma D., El-Samak A.A., Polymers to improve the world and lifestyle: physical, mechanical, and chemical needs, Polymer Science and Innovative Applications, pp. 1-19, (2020)
[2]  
Amereh F., Babaei M., Eslami A., Fazelipour S., Rafiee M., The emerging risk of exposure to nano (micro) plastics on endocrine disturbance and reproductive toxicity: from a hypothetical scenario to a global public health challenge, Environ. Pollut., 261, (2020)
[3]  
Andrady A.L., Microplastics in the marine environment, Mar. Pollut. Bull., 62, pp. 1596-1605, (2011)
[4]  
Annangi B., Villacorta A., Lopez-Mesas M., Fuentes-Cebrian V., Marcos R., Hernandez A., Hazard assessment of polystyrene nanoplastics in primary human nasal epithelial cells, focusing on the autophagic effects, Biomolecules, 13, (2023)
[5]  
Annangi B., Villacorta A., Vela L., Tavakolpournegari A., Marcos R., Hernandez A., Effects of true-to-life PET nanoplastics using primary human nasal epithelial cells, Environ. Toxicol. Pharmacol., 100, (2023)
[6]  
Baho D.L., Bundschuh M., Futter M.N., Microplastics in terrestrial ecosystems: moving beyond the state of the art to minimize the risk of ecological surprise, Global Change Biol., 27, pp. 3969-3986, (2021)
[7]  
Ballesteros S., Domenech J., Barguilla I., Cortes C., Marcos R., Hernandez A., Genotoxic and immunomodulatory effects in human white blood cells after ex vivo exposure to polystyrene nanoplastics, Environ. Sci.: Nano, 7, pp. 3431-3446, (2020)
[8]  
Benjamin S., Masai E., Kamimura N., Takahashi K., Anderson R.C., Faisal P.A., Phthalates impact human health: epidemiological evidences and plausible mechanism of action, J. Hazard Mater., 340, pp. 360-383, (2017)
[9]  
Bhattacharjee S., Ershov D., Islam M.A., Kampfer A.M., Maslowska K.A., van der Gucht J., Alink G.M., Marcelis A.T.M., Zuilhof H., Rietjens I.M.C.M., Role of membrane disturbance and oxidative stress in the mode of action underlying the toxicity of differently charged polystyrene nanoparticles, RSC Adv., 4, pp. 19321-19330, (2014)
[10]  
Biswas T., Pal S.C., Saha A., Ruidas D., Shit M, Islam A.R.M.T., Malafaia G., Microplastics in the coral ecosystems: a threat which needs more global attention, Ocean Coast Manag., 249, (2024)
12345678910