Global Evolution and Transmission Dynamics of Enterovirus D68

被引：0

作者：

Xiao, Mengyi ^{[1
,2
,3
]}

Han, Zhenzhi ^{[4
]}

Ma, Xiaozhen ^{[5
]}

Ji, Tianjiao ^{[2
,3
]}

Yan, Dongmei ^{[2
,3
]}

Wang, Dongyan ^{[2
,3
]}

Zhu, Shuangli ^{[2
,3
]}

Lu, Huanhuan ^{[2
,3
,6
]}

Cong, Ruyi ^{[1
,2
,3
,7
]}

Wang, Xiaoyi ^{[2
,3
,8
]}

Yang, Tingting ^{[2
,3
,9
]}

Liu, Ying ^{[2
,3
]}

Zhou, Lei ^{[2
,3
]}

Li, Fan ^{[2
,3
,10
]}

Liang, Yucai ^{[2
,3
,11
]}

Zhao, Linqing ^{[4
]}

Fan, Hua ^{[1
]}

Zhang, Yong ^{[2
,3
]}

Xiao, Jinbo ^{[2
,3
]}

机构：

[1] Shandong First Med Univ & Shandong Acad Med Sci, Sch Publ Hlth, Jinan, Peoples R China

[2] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing, Peoples R China

[3] Chinese Ctr Dis Control & Prevent, Natl Lab Poliomyelitis,Key Lab Biosafety, WHO WPRO Reg Polio Reference Lab,Key Lab Microbial, Natl Inst Viral Dis Control & Prevent,Natl Hlth Co, Beijing, Peoples R China

[4] Capital Inst Pediat, Lab Virol, Beijing Key Lab Etiol Viral Dis Children, Beijing, Peoples R China

[5] Sichuan Ctr Dis Control & Prevent, Chengdu, Peoples R China

[6] Chinese PLA Ctr Dis Control & Prevent, Beijing, Peoples R China

[7] North China Univ Sci & Technol, Sch Publ Hlth, Tangshan, Peoples R China

[8] Anhui Univ Sci & Technol, Med Sch, Huainan, Peoples R China

[9] Jinan Ctr Dis Control & Prevent, Jinan, Peoples R China

[10] Shenyang Med Coll, Shenyang, Peoples R China

[11] Shandong Second Med Univ, Dept Med Microbiol, Weifang, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2025年 / 97卷 / 07期

关键词：

Enterovirus D68; evolutionary analysis; phylogenetic analysis; phylogeography analysis; transmission; RESPIRATORY ILLNESS; MOLECULAR EVOLUTION; EMERGENCE; SEQUENCE; OUTBREAK; SEROTYPE; EUROPE;

D O I：

10.1002/jmv.70497

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Enterovirus D68 (EV-D68), a serotype of the enterovirus species D, has garnered significant attention due to outbreaks reported in 2014, 2016, and 2018. In this study, 36 Chinese EV-D68 strains were isolated, sequenced, and combined with all EV-D68 VP1 sequences from GenBank to form a data set of 1679 sequences. This data set served as the basis for phylogenetic, evolutionary dynamics, phylogeographic, and key amino acid site mutation analyses of EV-D68. Based on the VP1 region, EV-D68 is classified into four genotypes (A-D), and seven subgenotypes (B1-B3, D1-D4), with B3 and D3 being the predominant subgenotypes. Bayesian skyline plots indicated that genotypes B and D experienced multiple population expansions, aligning with reported EV-D68 outbreaks. Phylogeographic analyses of the B3 subgenotypes revealed sequences from Europe and North America clustering into a single evolutionary branch, suggesting significant transmission between these regions. Additionally, mutation analysis identified VP1-98 as a high-frequency mutation site, differing significantly between the previously prevalent A and C genotypes and the currently prevalent B and D genotypes. However, the functional implications of this mutation require further investigation. This study provides a solid theoretical basis for epidemiological research, disease surveillance, and prevention efforts related to EV-D68.

引用

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