Improved Solubility and Dissolution Release Profile of Lurasidone by Solid Self-Nanoemulsifying Drug Delivery System

被引：0

作者：

Dondapati D. ^{[1
]}

Srimathkandala M.H. ^{[1
]}

Sanka K. ^{[1
]}

Bakshi V. ^{[1
]}

机构：

[1] Department of Pharmaceutics, School of Pharmacy, (Formerly Lalitha College of Pharmacy), Anurag Group of Institutions, TS, Hyderabad

来源：

Analytical Chemistry Letters | 2016年 / 6卷 / 02期

关键词：

Aerosil[!sup]®[!/sup] 200; Dissolution release profile; Lurasidone; Self-nanoemulsifying drug delivery system; Zeta Average;

D O I：

10.1080/22297928.2016.1164075

中图分类号：

学科分类号：

摘要：

The purpose of the study was to investigate self-nanoemulsifying drug delivery system (SNEDDS) as potential delivery system for poorly water soluble drug Lurasidone (LUR). SNEDDS was formulated using oil (Anise oil) surfactant (Tween® 80), and co-surfactant (Polyethyleneglycol-600). Z-average size, PDI and in-vitro drug release were considered to screen and optimize the composition of liquid-SNEDDS. Following emulsification, the optimized formulation was selected to have the smallest mean particle size and highest absolute zeta potential, which would yield stable emulsion. Scanning electron microscopy, X-ray powder diffraction studies confirmed that there was no crystalline drug in Solid-SNEDDS. Fourier transform infrared (FTIR) spectroscopy study revealed that there was no measurable chemical interaction of drug with the carrier. There was no significance difference in zeta average, zeta potential, and release profile of developed formulation before and after stability study. Both Liquid-SNEDDS and solid-SNEDDS showed improved in-vitro drug release than the pure drug. This paper provides an overview of the SNEDDS of LUR as a promising alternative to improve solubility and dissolution release profile. The results suggested that the SNEDDS could be used as an effective oral dosage form to improve the oral delivery of poorly water soluble drug LUR. © 2016 Har Krishan Bhalla & Sons.

引用

页码：86 / 97

页数：11

共 33 条

[1]

Li B., Harich K., Wegiel L., Taylor L.S., Edgar K.J., Stability and solubility enhancement of ellagic acid in cellulose ester solid dispersions, Carbohydr Polym, 92, pp. 1443-1450, (2013)

[2]

Sinaca N.K., Kachrimanis K., Seka I.H., Gruji B., Duri Z., Ibri S., Solubility enhancement of desloratadine by solid dispersion in poloxamers, Int, J, Pharm, 436, pp. 161-170, (2012)

[3]

Kyatanwar A.U., Gajbhiye N.D., Jadhav K.R., Kadam V.J., Solid self emulsifying drug delivery system: a review, J, Pharm, Res, 3, pp. 877-882, (2010)

[4]

Chen Y.M., Lin P.C., Muoi T., Chen Y.P., Solid solubility of antilipemic agents and micronization of gemfibrozil in supercritical carbon dioxide, J, Supercrit, Fluids, 52, pp. 175-182, (2010)

[5]

Porter C.J., Pouton C.W., Cuine J.F., Charman W.N., Enhancing intestinal drug solubilisation using lipid-based delivery systems, Adv. Drug Deliv. Rev, 60, pp. 673-691, (2008)

[6]

Kommuru T.R., Gurley B., Khan M.A., Reddy I.K., Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment, Int. J. Pharm, 212, pp. 233-246, (2001)

[7]

Han X., Ghoroi C., To D., Chen Y., Dave R., Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles, Int. J. Pharm, 415, pp. 185-195, (2011)

[8]

Nepal P.R., Han H.K., Choi H.K., Enhancement of solubility and dissolution of Coenzyme Q10 using solid dispersion formulation, International Journal of Pharmaceutics, 383, pp. 147-153, (2010)

[9]

Franka K.J., Rosenblatt K.M., Westedt U., Holig P., Rosenberg J., Magerlein M., Fricker G., Brandla M., Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: True supersaturation vs. apparent solubility enhancement, Int. J. Pharm, 437, pp. 288-293, (2012)

[10]

Bari A., Chella N., Sanka K., Shastri N.R., Diwan P.V., Improved anti-diabetic activity of glibenclamide using oral self nano emulsifying powder, J. Microencapsul, 32, 1, pp. 54-60, (2015)

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