Editorial: Post-translational modifications in human cancer: pharmacological insights and therapeutic opportunities

被引：0

作者：

Chen, Yongzhi ^{[1
]}

Fan, Angelina W. ^{[2
]}

Huang, Lei ^{[3
]}

机构：

[1] Univ Massachusetts, Chan Med Sch, Dept Med, Div Innate Immun, Westborough, MA USA

[2] Westborough High Sch, Westborough, MA USA

[3] Univ Massachusetts, Chan Med Sch, Dept Mol Cell & Canc Biol, Worcester, MA 01655 USA

来源：

FRONTIERS IN PHARMACOLOGY | 2025年 / 16卷

关键词：

post-translational modifications; PTMs; cancer; personalized medicine; PARP inhibitor; UPS inhibitor; SUMOylation inhibitors;

D O I：

10.3389/fphar.2025.1654659

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页数：3

共 11 条

[1] Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review [J].

Biller, Leah H. ;

Schrag, Deborah .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (07) :669-685

[2] The Function of SUMOylation and Its Critical Roles in Cardiovascular Diseases and Potential Clinical Implications [J].

Du, Congcong ;

Chen, Xu ;

Su, Qi ;

Lu, Wenbin ;

Wang, Qiqi ;

Yuan, Hong ;

Zhang, Zhenzhen ;

Wang, Xiaotong ;

Wu, Hongmei ;

Qi, Yitao .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (19)

[3] The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications [J].

Duan, Xiaohong ;

Xing, Zhiyao ;

Qiao, Lu ;

Qin, Shan ;

Zhao, Xuejing ;

Gong, Yanhua ;

Li, Xueren .

FRONTIERS IN IMMUNOLOGY, 2024, 15

[4] Post-translational modifications and their implications in cancer [J].

Dutta, Hashnu ;

Jain, Nishant .

FRONTIERS IN ONCOLOGY, 2023, 13

[5] Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection [J].

Fabbrizi, Emanuele ;

Fiorentino, Francesco ;

Carafa, Vincenzo ;

Altucci, Lucia ;

Mai, Antonello ;

Rotili, Dante .

CELLS, 2023, 12 (06)

[6] Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation [J].

Geffen, Yifat ;

Anand, Shankara ;

Akiyama, Yo ;

Yaron, Tomer M. ;

Song, Yizhe ;

Johnson, Jared L. ;

Govindan, Akshay ;

Babur, Ozgun ;

Li, Yize ;

Huntsman, Emily ;

Wang, Liang-Bo ;

Birger, Chet ;

Heiman, David I. ;

Zhang, Qing ;

Miller, Mendy ;

Maruvka, Yosef E. ;

Haradhvala, Nicholas J. ;

Calinawan, Anna ;

Belkin, Saveliy ;

Kerelsky, Alexander ;

Clauser, Karl R. ;

Krug, Karsten ;

Satpathy, Shankha ;

Payne, Samuel H. ;

Mani, D. R. ;

Gillette, Michael A. ;

Dhanasekaran, Saravana M. ;

Thiagarajan, Mathangi ;

Mesri, Mehdi ;

Rodriguez, Henry ;

Robles, Ana I. ;

Carr, Steven A. ;

Lazar, Alexander J. ;

Aguet, Francois ;

Cantley, Lewis C. ;

Ding, Li ;

Getz, Gad .

CELL, 2023, 186 (18) :3945-3967.e26

[7] PRMT5 activates AKT via methylation to promote tumor metastasis [J].

Huang, Lei ;

Zhang, Xiao-Ou ;

Rozen, Esteban J. ;

Sun, Xiaomei ;

Sallis, Benjamin ;

Verdejo-Torres, Odette ;

Wigglesworth, Kim ;

Moon, Daniel ;

Huang, Tingting ;

Cavaretta, John P. ;

Wang, Gang ;

Zhang, Lei ;

Shohet, Jason M. ;

Lee, Mary M. ;

Wu, Qiong .

NATURE COMMUNICATIONS, 2022, 13 (01)

[8] The impact of dysregulation SUMOylation on prostate cancer [J].

Li, Kailang ;

Wang, Haifeng ;

Jiang, Bitao ;

Jin, Xiaofeng .

JOURNAL OF TRANSLATIONAL MEDICINE, 2025, 23 (01)

[9] Advances in post-translational modifications of proteins and cancer immunotherapy [J].

Li, Yanqing ;

Zhang, Runfang ;

Hei, Hu .

FRONTIERS IN IMMUNOLOGY, 2023, 14

[10] The Critical Roles of the SUMO-Specific Protease SENP3 in Human Diseases and Clinical Implications [J].

Long, Xiaojun ;

Zhao, Biying ;

Lu, Wenbin ;

Chen, Xu ;

Yang, Xinyi ;

Huang, Jifang ;

Zhang, Yuhong ;

An, Siming ;

Qin, Yuanyuan ;

Xing, Zhengcao ;

Shen, Yajie ;

Wu, Hongmei ;

Qi, Yitao .

FRONTIERS IN PHYSIOLOGY, 2020, 11

← 1 2 →