A Cell Biologist's View on APOL1: What We Know and What We Still Need to Address

被引：0

作者：

Hoeffken, Verena ^{[1
]}

Braun, Daniela Anne ^{[1
]}

Pavenstaedt, Hermann ^{[1
]}

Weide, Thomas ^{[1
]}

机构：

[1] Univ Hosp Munster, Med Clin D, D-48147 Munster, Germany

来源：

CELLS | 2025年 / 14卷 / 13期

关键词：

APOL1; Apolipoprotein L1; APOL1-mediated kidney disease; AMKD; renal risk variants; nephrotoxicity; topology; ion pore; ENDOPLASMIC-RETICULUM STRESS; LIPID-BINDING PROTEIN; APOLIPOPROTEIN L1; KIDNEY-DISEASE; RISK VARIANTS; MEMBRANE; GENE; CYTOTOXICITY; EXPRESSION; RESISTANCE;

D O I：

10.3390/cells14130960

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

APOL1 is the most recent member of the APOL gene family and is expressed exclusively in humans and a few higher primates. More than twenty years ago, it was discovered that APOL1 protects humans from infections by trypanosome subspecies that cause African sleeping sickness. Interestingly, by a co-evolutionary process between parasite and host, two APOL1 variants emerged, which, in addition to their trypanotoxic effects, are simultaneously associated with a significantly increased risk for various different kidney diseases, which are now summarized as APOL1-mediated kidney diseases (AMKDs). The aim of this review is to highlight and formulate key aspects of APOL1's cell biologic features, including questions and unaddressed aspects. This perspective may contribute to a deeper understanding of APOL1-associated cytotoxicity as well as AMKDs.

引用

页数：24

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