Suprachiasmatic Nucleus Vasoactive Intestinal Peptide Neurons Mediate Light-induced Transient Forgetting

被引：0
作者：
Su, Xiaoya [1 ,2 ,3 ]
Tang, Yikai [1 ]
Zhong, Yi [1 ,2 ,3 ,4 ]
Liu, Yunlong [1 ,5 ]
机构：
[1] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
[2] McGovern Inst Brain Res, Beijing 100084, Peoples R China
[3] Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China
[4] Tsinghua Univ, MOE Key Lab Prot Sci, Beijing 100084, Peoples R China
[5] Hosp Sick Children, Neurosci & Mental Hlth, Toronto, ON M1L3V2, Canada
来源：
NEUROSCIENCE BULLETIN | 2025年
基金：
中国国家自然科学基金;
关键词：
Light; Transient forgetting; Suprachiasmatic nucleus; Vasoactive intestinal peptide neurons; CIRCADIAN-RHYTHMS; GLOBAL AMNESIA; MEMORY; SLEEP; ORGANIZATION; ULTRAVIOLET; CIRCUITS;
D O I：
10.1007/s12264-025-01456-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Our research reveals the critical role of the suprachiasmatic nucleus (SCN) vasoactive intestinal peptide (VIP) neurons in mediating light-induced transient forgetting. Acute exposure to bright light selectively impairs trace fear memory by activating VIP neurons in the SCN, as demonstrated by increased c-Fos expression and Ca2+ recording. This effect can be replicated and reversed through optogenetic and chemogenetic manipulations of SCN VIP neurons. Furthermore, we identify the SCN -> PVT (paraventricular nucleus of the thalamus) VIP neuronal circuitry as essential in this process. These findings establish a novel role for SCN VIP neurons in modulating memory accessibility in response to environmental light cues, extending their known function beyond circadian regulation and revealing a mechanism for transient forgetting.
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页数：11
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