Mapping the regulatory genetic landscape of complex traits using a chicken advanced intercross line

被引：0

作者：

Zhu, Xiaoning ^{[1
,2
,3
]}

Li, Chong ^{[1
]}

Luo, Chenglong ^{[4
]}

Bai, Zhonghao ^{[3
]}

Shu, Dingming ^{[2
,4
]}

Chen, Peng ^{[4
]}

Ren, Jiangli ^{[1
,5
]}

Song, Ran ^{[1
,5
]}

Fang, Lingzhao ^{[3
]}

Qu, Hao ^{[2
,4
]}

Wang, Yuzhe ^{[1
,5
,6
]}

Hu, Xiaoxiang ^{[1
,5
,6
]}

机构：

[1] China Agr Univ, Coll Biol Sci, State Key Lab Anim Biotech Breeding, Beijing, Peoples R China

[2] State Key Lab Swine & Poultry Breeding Ind, Guangzhou, Peoples R China

[3] Aarhus Univ, Ctr Quantitat Genet & Genom QGG, Aarhus, Denmark

[4] Guangdong Acad Agr Sci, Inst Anim Sci, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou, Peoples R China

[5] China Agr Univ, Natl Res Facil Phenotyp & Genotyp Anal Model Anim, Beijing, Peoples R China

[6] China Agr Univ, Frontiers Sci Ctr Mol Design Breeding, MOE, Beijing, Peoples R China

来源：

NATURE COMMUNICATIONS | 2025年 / 16卷 / 01期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

GENOME; ASSOCIATION; POPULATION; EVOLUTION; DISCOVERY; FRAMEWORK; GROWTH; GWAS; TOOL;

D O I：

10.1038/s41467-025-60834-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Complex traits exhibit a highly polygenic architecture that complicates gene mapping and molecular characterization. As a model organism for birds, chickens possess high-quality reference panels, functional annotations, and molecular quantitative trait locus maps. However, the genetic mechanisms underlying growth traits have not been systematically analyzed. Here, we develop a 16-generation advanced intercross line of chickens to enhance informative recombination and identify 154 single-gene quantitative trait loci. We use multiple co-localization methods to establish a network landscape of tissue-specific regulatory mutations and functional gene relationships. We leverage gene-clustering and restoration quantitative trait loci within the omnigenic model framework to elucidate the genetic regulation system of growth traits. Cross-species comparisons show the conserved functions of growth-related genes and divergent features of regulatory mechanisms in mammals and birds.

引用

页数：15

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