Treatment of infected wounds with cold atmospheric plasma: a case series

被引:0
作者
Ricci, Elia [1 ]
Pittarello, Monica [1 ]
Ricci, Andrea [1 ]
Ascher, Stefanie [2 ]
Gebhardt, Lisa [2 ]
机构
[1] Polyclin Monza, Eporediese Clin Ivrea, Vulnol Unit, Ivrea, Italy
[2] Terraplasma Med GmbH, Garching Near Munich, Munich, Germany
关键词
bacterial load; chronic wound; cold atmospheric plasma; hard-to-heal; infected wound; non-invasive physical plasma; wound; wound bed preparation; wound care; wound dressing; wound healing; SKIN; ANGIOGENESIS; STIMULATION; BIOFILMS;
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Due to its inactivating effect on bacteria, cold atmospheric plasma (CAP) has been shown to be successful in the treatment of hard-to-heal (chronic) and infected wounds. In this case series, 15 patients with a total of 20 wounds were treated with a mobile CAP device and the bacterial load of the wound simultaneously observed using a MolecuLight i:X (MolecuLight Inc., US) camera. In 60% of cases, the bacterial load could be brought under control despite minimal CAP application. This procedure offers the advantage of being able to directly visualise wound bacterial load and, therefore, the inactivation of bacteria is also directly visible. The use of the two devices complemented each other; supporting wound management and analysis of its effectiveness. Declaration of interest: This research study was sponsored by terraplasma medical GmbH, Germany, and Medical Group S.R.L., Italy. The device and spacers were provided for the duration of the data collection free of charge.
引用
收藏
页码:506 / 512
页数:7
相关论文
共 34 条
[1]  
Apelqvist J, 2024, J Wound Manage, V25, pS1, DOI [10.35279/jowm2024.25.03.sup01, DOI 10.35279/JOWM2024.25.03.SUP01]
[2]   Non-thermal dielectric barrier discharge plasma induces angiogenesis through reactive oxygen species [J].
Arjunan, Krishna Priya ;
Friedman, Gary ;
Fridman, Alexander ;
Clyne, Alisa Morss .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2012, 9 (66) :147-157
[3]   Cold atmospheric plasma (CAP) activates angiogenesis-related molecules in skin keratinocytes, fibroblasts and endothelial cells and improves wound angiogenesis in an autocrine and paracrine mode [J].
Arndt, Stephanie ;
Unger, Petra ;
Berneburg, Mark ;
Bosserhoff, Anja-Katrin ;
Karrer, Sigrid .
JOURNAL OF DERMATOLOGICAL SCIENCE, 2018, 89 (02) :181-190
[4]   Effects and safety of atmospheric low-temperature plasma on bacterial reduction in chronic wounds and wound size reduction: A systematic review and meta-analysis [J].
Assadian, Ojan ;
Ousey, Karen J. ;
Daeschlein, George ;
Kramer, Axel ;
Parker, Christina ;
Tanner, Judith ;
Leaper, David J. .
INTERNATIONAL WOUND JOURNAL, 2019, 16 (01) :103-111
[5]  
AWMF online, 2022, Guideline: S2k guideline: Rational therapeutic use of cold physical plasma
[6]   Effects of cold atmospheric plasma (CAP) on bacteria and mucosa of the upper aerodigestive tract [J].
Becker, Sven ;
Zimmermann, Julia L. ;
Baumeister, Philipp ;
Brunner, Theresa F. ;
Shimizu, Tetsuji ;
Li, Yang-Fang ;
Morfill, Gregor E. ;
Harreus, Ulrich ;
Welz, Christian .
AURIS NASUS LARYNX, 2019, 46 (02) :294-301
[7]   Antibacterial and safety tests of a flexible cold atmospheric plasma device for the stimulation of wound healing [J].
Boekema, Bouke ;
Stoop, Matthea ;
Vlig, Marcel ;
van Liempt, Jos ;
Sobota, Ana ;
Ulrich, Magda ;
Middelkoop, Esther .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2021, 105 (05) :2057-2070
[8]  
Cutting K F, 1994, J Wound Care, V3, P198
[9]  
Daeschlein G, 2015, J DTSCH DERMATOL GES, V13, P143, DOI [10.1111/ddg.12559, 10.1111/ddg.12559_suppl]
[10]   In Vitro Susceptibility of Multidrug Resistant Skin and Wound Pathogens Against Low Temperature Atmospheric Pressure Plasma Jet (APPJ) and Dielectric Barrier Discharge Plasma ( DBD) [J].
Daeschlein, Georg ;
Napp, Matthias ;
von Podewils, Sebastian ;
Lutze, Stine ;
Emmert, Steffen ;
Lange, Anja ;
Klare, Ingo ;
Haase, Hermann ;
Guembel, Denis ;
von Woedtke, Thomas ;
Juenger, Michael .
PLASMA PROCESSES AND POLYMERS, 2014, 11 (02) :175-183