Exosome biosensors for the detection of breast cancer

被引：0

作者：

Sadeghi, Mohammad Hassan ^{[1
]}

Kheradi, Niloufar ^{[2
]}

Nazem, Shima ^{[3
]}

Amirsaadat, Soumayeh ^{[4
]}

Ashourpour, Maryam ^{[5
]}

Chegeni, Sara Aghakhani ^{[5
]}

Sohrabi, Sepideh ^{[6
]}

Sani, Maryam Zamani ^{[5
]}

Movahedpour, Ahmad ^{[7
]}

Dolatabadi, Elham Norouz ^{[8
]}

Ehtiati, Sajad ^{[9
]}

机构：

[1] Zahedan Univ Med Sci, Sch Med, Zahedan, Iran

[2] Tabriz Univ Med Sci, Mol Med Res Ctr, Tabriz, Iran

[3] Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran

[4] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[5] Tabriz Univ Med Sci, Fac Med, Dept Clin Biochem & Lab Sci, Tabriz, Iran

[6] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[7] Yasuj Univ Med Sci, Cellular & Mol Res Ctr, Yasuj, Iran

[8] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Biotechnol, Tabriz, Iran

[9] Shahid Beheshti Univ Med Sci, Sch Med, Student Res Comm, Dept Clin Biochem, Tehran, Iran

来源：

CLINICA CHIMICA ACTA | 2025年 / 577卷

关键词：

Exosomes; Breast Cancer; Biomarker; Optical; Electrochemical; Electrical; Biosensors; BIOGENESIS;

D O I：

10.1016/j.cca.2025.120456

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Breast cancer, the most common malignancy in women, is difficult to identify early with conventional techniques like biopsy and mammography, which are frequently invasive and prone to false negative results. Exosome-based detection is a novel, non-invasive diagnostic technique made possible by recent developments in biosensor technology. Exosomes, which are tiny extracellular vesicles released by cells, include biomarkers including microRNAs and oncogenic proteins that offer vital information about the occurrence and spread of breast cancer. By identifying exosomal biomarkers, biosensors use high sensitivity, specificity, and real-time analysis to facilitate early cancer detection, individualized treatment plans, and better patient outcomes. This review explores the biology of exosomes and their roles in intercellular communication, cancer progression, and therapeutic potential. It further examines the development and application of electrochemical, optical, and electrical biosensors for the detection of breast cancer-derived exosomes.

引用

页数：8

共 108 条

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