Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region

被引：8

作者：

Tada, Hayato ^{[1
]}

Yeo, Khung Keong ^{[2
,3
]}

Li, Jian-Jun ^{[4
]}

Tan, Kathryn ^{[5
]}

Ako, Junya ^{[6
]}

Krittayaphong, Rungroj ^{[7
]}

Tan, Ru San ^{[2
,3
]}

Aylward, Philip E. ^{[8
,9
]}

Lam, Carolyn S. P. ^{[2
,3
]}

Baek, Sang Hong ^{[10
]}

Dalal, Jamshed ^{[11
]}

Fong, Alan ^{[12
,13
]}

Li, Yi-Heng ^{[14
]}

O'Brien, Richard C. ^{[15
,16
]}

Koh, Si Ya Natalie ^{[2
,3
]}

Scherer, Daniel J. ^{[17
]}

Kang, Vernon ^{[18
]}

Nelson, Adam J. ^{[19
]}

Butters, Julie ^{[19
]}

Nicholls, Stephen J. ^{[19
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Kanazawa, Japan

[2] Natl Heart Ctr, Singapore, Singapore

[3] SingHealth Duke NUS Cardiovasc Sci, Singapore, Singapore

[4] Chinese Acad Med Sci & Peking Union Med Coll, FuWai Hosp, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China

[5] Univ Hong Kong, Dept Med, Hong Kong, Peoples R China

[6] Kitasato Univ, Sagamihara, Japan

[7] Mahidol Univ, Siriraj Hosp, Dept Med, Div Cardiol, Bangkok, Thailand

[8] South Australian Hlth & Med Res Inst, Adelaide, SA, Australia

[9] Flinders Univ S Australia, Adelaide, SA, Australia

[10] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Seoul, South Korea

[11] Kokilaben Hosp, Mumbai, Maharashtra, India

[12] Sarawak Gen Hosp, Sarawak Heart Ctr, Dept Cardiol, Kuching, Malaysia

[13] Sarawak Gen Hosp, Clin Res Ctr, Kuching, Malaysia

[14] Natl Cheng Kung Univ Hosp, Tainan, Taiwan

[15] Univ Melbourne, Melbourne, Vic, Australia

[16] Austin Hlth, Melbourne, Vic, Australia

[17] South Australian Hlth & Med Res Inst, Adelaide, SA, Australia

[18] Singapore Heart Fdn, Singapore, Singapore

[19] Monash Univ, Victorian Heart Inst, Melbourne, Vic, Australia

来源：

JACC-ASIA | 2021年 / 1卷 / 03期

关键词：

Asia-Pacific; cardiovascular disease; genetics; polygenic risk score; CORONARY-HEART-DISEASE; GENOME-WIDE ASSOCIATION; GENETIC RISK; ARTERY-DISEASE; FAMILIAL HYPERCHOLESTEROLEMIA; CLINICAL-PERSPECTIVES; PROSPECTIVE COHORT; PREDICTION; INDIVIDUALS; PREVALENCE;

D O I：

10.1016/j.jacasi.2021.08.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Approximately one-half of the phenotypic susceptibility to atherosclerotic cardiovascular disease (ASCVD) has a genetic basis. Although individual allelic variants generally impart a small effect on risk for ASCVD, an emerging body of data has shown that the aggregation and weighting of many of these genetic variations into "scores" can further discriminate an individual's risk beyond traditional risk factors alone. Consistent with the theory of population genetics, such polygenic risk scores (PRS) appear to be ethnicity specific because their elements comprise single-nucleotide variants that are always ethnicity specific. The currently available PRS are derived predominantly from European ancestry and thus predictably perform less well among non-European participants, a fact that has implications for their use in the Asia-Pacific region. This paper describes the current state of knowledge of PRS, the available data that support their use in this region, and highlights the needs moving forward to safely and effectively implement them in clinical care in the Asia-Pacific region. (JACC: Asia 2021;1:294-302) (c) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：294 / 302

页数：9

共 46 条

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