Late-Stage Aryl C-H Bond Carboxylation with CO2 via Combining Metal-Free C-H Bond Borylation and ZnEt2-Promoted C-B Bond Carboxylation

被引：0

作者：

Yang, Ke ^{[1
]}

Tang, Shibiao ^{[1
]}

Liu, Zezhao ^{[1
]}

Zhang, Yongxin ^{[1
]}

Li, Bin ^{[1
]}

Wang, Baiquan ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Chem, Frontiers Sci Ctr New Organ Matter, State Key Lab Elemento Organ Chem, Tianjin 300071, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 28期

基金：

中国国家自然科学基金;

关键词：

CARBON-DIOXIDE; CATALYZED CARBOXYLATION; ESTERS; TRANSFORMATION; HYDROXYLATION;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel one-pot, two-step strategy for late-stage aryl ortho-C-H bond carboxylation of anilines with CO2 has been developed. This methodology combines BBr3-mediated aryl ortho-C-H bond borylation and ZnEt2-promoted C-B bond carboxylation, enabling the efficient synthesis of diverse ortho-aminobenzoic acid derivatives. The protocol eliminates the requirement for precious metal catalysts and bulky non-labile directing groups, potentially serving as an efficient approach for installing a carboxylic acid group in functional molecules.

引用

页码：7577 / 7583

页数：7

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