A meta-analysis of the effects of proton pump inhibitors on the risk of gastric cancer

被引：0

作者：

Zhang, Hao ^{[1
]}

Meng, Xianyu ^{[2
]}

Gou, Dongyun ^{[3
]}

Liu, Xiaojing ^{[4
]}

Huang, Yu ^{[5
]}

Liu, Siyu ^{[6
]}

Wang, Haiyang ^{[2
]}

Li, Hongyan ^{[2
]}

机构：

[1] Second Peoples Hosp Hengshui City, Dept Abdominal Surg, Hengshui, Hebei, Peoples R China

[2] Hebei Med Univ, Hosp 3, Dept Gastrointestinal Surg, 139 Ziqiang Rd, Shijiazhuang, Hebei, Peoples R China

[3] Hebei Med Univ, Hosp 1, Med Affairs Dept, Med Record Room, Shijiazhuang, Hebei, Peoples R China

[4] Hengshui Univ, Sch Math & Comp Sci, Hengshui, Peoples R China

[5] Hebei Med Univ, Hosp 3, Dept Vasc Surg, Shijiazhuang, Hebei, Peoples R China

[6] Hebei Univ, Affiliated Hosp, Gen Surg Dept, Baoding, Hebei, Peoples R China

来源：

MEDICINE | 2025年 / 104卷 / 28期

关键词：

gastric cancer; meta-analysis; proton pump inhibitors; risk factors; ADENOCARCINOMA; ASSOCIATION; ESOPHAGEAL; INFECTION;

D O I：

10.1097/MD.0000000000043053

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background:Proton pump inhibitors (PPIs) are commonly prescribed drugs in clinical practice, mainly for the treatment of Helicobacter pylori infection and gastroesophageal reflux disease (GERD). With the application of PPIs, doctors have found a variety of adverse reactions related to it, with gastric cancer being the most serious. Our aim is to investigate whether the use of PPIs increases the probability of gastric cancer.Methods:By searching PubMed, EMBASE, the Cochrane Library and Web of science, references related to PPIs and gastric cancer were selected, and Newcastle-Ottawa scale (NOS) was used to evaluate the quality of the included references and analyze their bias. Then stataSE-64 was used for statistical analysis. The above processes were independently searched and evaluated by 2 researchers.Results:The use of PPIs significantly increased the incidence of gastric cancer (RR = 1.75, 95% CI: 1.48-2.07, P = .000).Conclusion:Long-term use of PPIs may increase the incidence of gastric cancer.

引用

页数：8

共 36 条

[1] Proton pump inhibitors and risk of gastric cancer: population-based cohort study [J].

Abrahami, Devin ;

McDonald, Emily Gibson ;

Schnitzer, Mireille E. ;

Barkun, Alan N. ;

Suissa, Samy ;

Azoulay, Laurent .

GUT, 2022, 71 (01) :16-24

[2] Adenocarcinoma arising in multiple hyperplastic polyps in a patient with Helicobacter pylori infection and hypergastrinemia during long-term proton pump inhibitor therapy [J].

Anjiki H. ;

Mukaisho K.-I. ;

Kadomoto Y. ;

Doi H. ;

Yoshikawa K. ;

Nakayama T. ;

Vo D.T.-N. ;

Hattori T. ;

Sugihara H. .

Clinical Journal of Gastroenterology, 2017, 10 (2) :128-136

[3] Signet ring cells in gastric carcinomas are derived from neuroendocrine cells [J].

Bakkelund, Karin ;

Fossmark, Reidar ;

Nordrum, Ivar ;

Waldum, Helge .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2006, 54 (06) :615-621

[4] Proton pump inhibitor use and risk of adverse cardiovascular events in aspirin treated patients with first time myocardial infarction: nationwide propensity score matched study [J].

Charlot, Mette ;

Grove, Erik L. ;

Hansen, Peter Riis ;

Olesen, Jonas B. ;

Ahlehoff, Ole ;

Selmer, Christian ;

Lindhardsen, Jesper ;

Madsen, Jan Kyst ;

Kober, Lars ;

Torp-Pedersen, Christian ;

Gislason, Gunnar H. .

BRITISH MEDICAL JOURNAL, 2011, 342

[5] Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study [J].

Cheung, Ka Shing ;

Chan, Esther W. ;

Wong, Angel Y. S. ;

Chen, Lijia ;

Wong, Ian C. K. ;

Leung, Wai Keung .

GUT, 2018, 67 (01) :28-35

[6] Gastric Cancer: Overview [J].

Correa, Pelayo .

GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2013, 42 (02) :211-+

[7] Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease [J].

Dial, S ;

Delaney, JAC ;

Barkun, AN ;

Suissa, S .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (23) :2989-2995

[8] Antacid Drug Use and Risk of Esophageal and Gastric Adenocarcinomas in Los Angeles County [J].

Duan, Lei ;

Wu, Anna H. ;

Sullivan-Halley, Jane ;

Bernstein, Leslie .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (02) :526-533

[9] Gastric acid suppression and risk of oesophageal and gastric adenocarcinoma: a nested case control study in the UK [J].

Garcia Rodriguez, L. A. ;

Lagergren, J. ;

Lindblad, M. .

GUT, 2006, 55 (11) :1538-1544

[10] Association of Proton Pump Inhibitors With Risk of Dementia A Pharmacoepidemiological Claims Data Analysis [J].

Gomm, Willy ;

von Holt, Klaus ;

Thome, Friederike ;

Broich, Karl ;

Maier, Wolfgang ;

Fink, Anne ;

Doblhammer, Gabriele ;

Haenisch, Britta .

JAMA NEUROLOGY, 2016, 73 (04) :410-416

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