Ferroptosis as a potential therapeutic target for obesity-related metabolic diseases

被引：0
作者：
Huang, Chao-Dong [1 ]
Luo, Tao [2 ]
Zhang, Hua [3 ,4 ]
Cheng, Lin-Hui [5 ]
Peng, Shu-Hong [6 ]
Zhou, Xiao-Wei [7 ]
Cao, Lan [1 ]
Chen, Fang-You [1 ]
He, Jun-Wei [1 ]
Chen, Chen [8 ]
Zhang, Chang-Hua [1 ,4 ]
Zhang, Yu-Ai [9 ]
Zhong, Ling-Yun [1 ]
机构：
[1] Jiangxi Univ Chinese Med, Coll Pharm, Nanchang, Jiangxi, Peoples R China
[2] Nanchang Univ, Affiliated Hosp 1, Blood Purificat Ctr, Nanchang, Peoples R China
[3] Nanchang Univ, Affiliated Hosp 3, Jiangxi Med Coll, Dept Radiol, Nanchang, Peoples R China
[4] First Hosp Nanchang, Dept Radiol, Nanchang, Peoples R China
[5] Sun Yat Sen Univ, Nanchang Res Inst, Nanchang, Jiangxi, Peoples R China
[6] Jiangxi Univ Chinese Med, Res Ctr Differentiat & Dev TCM Basic Theories, Nanchang, Jiangxi, Peoples R China
[7] Changzhou West Taihu Sci & Technol Ind Pk Manageme, Changzhou, Jiangshu, Peoples R China
[8] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia
[9] Fudan Univ, Sch Pharm, Shanghai, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2025年 / 16卷
基金：
澳大利亚国家健康与医学研究理事会; 中国国家自然科学基金;
关键词：
ferroptosis; obesity-related metabolic diseases; occurrence and regulation of ferroptosis; pharmacotherapy strategy; potential therapeutic targets; ISCHEMIA-REPERFUSION INJURY; CELL-DEATH; PROMOTES FERROPTOSIS; LIPID-PEROXIDATION; EPITHELIAL-CELLS; DOWN-REGULATION; LIVER; MECHANISMS; IRON; EPIDEMIOLOGY;
D O I：
10.3389/fphar.2025.1581632
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Obesity represents one of the major public health issues threatening the global health and promoting chronic metabolic disorders, including type 2 diabetes, insulin resistance (IR), hyperlipidemia, hypertension, polycystic ovary syndrome, metabolic-associated fatty liver disease (MAFLD), and others. Ferroptosis, a novel form of cell death, is a programmed cell death induced by iron-dependent lipid peroxidation. It is characterized by excessive iron accumulation and unregulated lipid peroxidation. The activity of ferroptosis is modulated by multiple factors such as iron, reactive oxygen species, and over 98 unsaturated fatty acids. Mounting evidence indicates that ferroptosis plays a crucial role in obesity-related chronic metabolic diseases like type 2 diabetes, IR, hyperlipidemia, hypertension, polycystic ovary syndrome, and MAFLD. Clarifying the molecular mechanism of ferroptosis may discover potential therapeutic targets for the treatment of these diseases. This article comprehensively reviews the role, pathogenesis, prevention, treatment strategies, current research gaps and future development directions of ferroptosis in obesity-related chronic metabolic diseases have been thoroughly discussed, and novel perspectives for the future treatment and research of ferroptosis in these diseases carefully provided. It points out directions for basic research on ferroptosis, raises urgent needs for developing precise intervention strategies, and provides new insights into the treatment and study of obesity-related chronic metabolic diseases in the future.
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页数：18
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