Electrophysiological Mechanisms and Therapeutic Potential of Calcium Channels in Atrial Fibrillation

被引:0
作者
Huang, Zuyuan [1 ]
Luo, Cheng [1 ]
Wu, Zimin [1 ]
Zheng, Baoshi [1 ]
机构
[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Cardiovasc Surg, Nanning 530021, Guangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
atrial fibrillation; calcium channels; calcium homeostasis; electrophysiology; therapeutic targets; RYANODINE RECEPTOR FUNCTION; INDUCED CARDIAC FIBROSIS; DEPENDENT CA2+ RELEASE; HEART-FAILURE; DOWN-REGULATION; KINASE-II; INHIBITION; CAMKII; TRPM7; CRAC;
D O I
10.31083/RCM33507
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Atrial fibrillation (AF) is a prevalent and complex arrhythmia for which the pathogenesis involves various electrophysiological factors, notably the regulation of calcium channels. This article aimed to investigate the specific roles and molecular mechanisms of the L-type and T-type calcium channels, ryanodine receptors (RyRs), inositol 1,4,5-triphosphate receptors (IP3Rs), calcium release-activated calcium (CRAC) channels, and transient receptor potential (TRP) channels in the pathogenesis and persistence of AF. In addition, this article reviews recent advances in calcium channel-targeted drugs from experimental and clinical studies, offering new insights into the relationship between calcium channel regulation and AF pathology. These findings suggest promising directions for further research into the mechanisms of AF and the development of targeted therapeutic strategies.
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页数:17
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共 157 条
[21]   A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo [J].
Davis, Jennifer ;
Burr, Adam R. ;
Davis, Gregory F. ;
Birnbaumer, Lutz ;
Molkentin, Jeffery D. .
DEVELOPMENTAL CELL, 2012, 23 (04) :705-715
[22]   Ca2+ entry through plasma membrane IP3 receptors [J].
Dellis, Olivier ;
Dedos, Skarlatos G. ;
Tovey, Stephen C. ;
Taufiq-Ur-Rahman ;
Dubel, Stefan J. ;
Taylor, Colin W. .
SCIENCE, 2006, 313 (5784) :229-233
[23]   Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure [J].
Denham, Nathan C. ;
Pearman, Charles M. ;
Caldwell, Jessica L. ;
Madders, George W. P. ;
Eisner, David A. ;
Trafford, Andrew W. ;
Dibb, Katharine M. .
FRONTIERS IN PHYSIOLOGY, 2018, 9
[24]   Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus [J].
Derler, Isabella ;
Butorac, Carmen ;
Krizova, Adela ;
Stadlbauer, Michael ;
Muik, Martin ;
Fahrner, Marc ;
Frischauf, Irene ;
Romanin, Christoph .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (04) :1259-1270
[25]   Graded Ca2+/calmodulin-dependent coupling of voltage-gated Cav1.2 channels [J].
Dixon, Rose E. ;
Moreno, Claudia M. ;
Yuan, Can ;
Opitz-Araya, Ximena ;
Binder, Marc D. ;
Navedo, Manuel F. ;
Santana, Luis F. .
ELIFE, 2015, 4
[26]   IP3 receptor-dependent Ca2+ release modulates excitation-contraction coupling in rabbit ventricular myocytes [J].
Domeier, Timothy L. ;
Zima, Aleksey V. ;
Maxwell, Joshua T. ;
Huke, Sabine ;
Mignery, Gregory A. ;
Blatter, Lothar A. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2008, 294 (02) :H596-H604
[27]   Natriuretic Peptide Receptor B Protects Against Atrial Fibrillation by Controlling Atrial cAMP Via Phosphodiesterase 2 [J].
Dorey, Tristan W. ;
Liu, Yingjie ;
Jansen, Hailey J. ;
Bohne, Loryn J. ;
Mackasey, Martin ;
Atkinson, Logan ;
Prasai, Shuvam ;
Belke, Darrell D. ;
Fatehi-Hassanabad, Ali ;
Fedak, Paul W. M. ;
Rose, Robert A. .
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2023, 16 (11) :620-635
[28]   Leukocyte TRP channel gene expressions in patients with non-valvular atrial fibrillation [J].
Duzen, Irfan V. ;
Yavuz, Fethi ;
Vuruskan, Ertan ;
Saracoglu, Erhan ;
Poyraz, Fatih ;
Goksuluk, Huseyin ;
Candemir, Basar ;
Demiryurek, Seniz .
SCIENTIFIC REPORTS, 2017, 7
[29]  
Elliott AD, 2023, NAT REV CARDIOL, V20, P404, DOI 10.1038/s41569-022-00820-8
[30]   Social determinants of atrial fibrillation [J].
Essien, Utibe R. ;
Kornej, Jelena ;
Johnson, Amber E. ;
Schulson, Lucy B. ;
Benjamin, Emelia J. ;
Magnani, Jared W. .
NATURE REVIEWS CARDIOLOGY, 2021, 18 (11) :763-773