From Nuclear Receptor Regulation to Spleen Activating and Accumulation Resolving Therapy: A Review of Traditional Chinese Medicine Against Diabetes and Inflammation

被引：0

作者：

Huang, Jiawen ^{[1
]}

Xu, Like ^{[1
]}

Liu, Weiru ^{[1
]}

Lin, Chuanquan ^{[1
]}

Tang, Ying ^{[1
]}

Shen, Chuangpeng ^{[1
]}

Gao, Yong ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, State Key Lab Tradit Chinese Med Syndrome, Guangzhou 510405, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 13期

基金：

中国国家自然科学基金;

关键词：

diabetes; nuclear receptors; metabolism; inflammation; drug; Chinese medicine; REVERSES INSULIN-RESISTANCE; PPAR-ALPHA AGONIST; LIVER X RECEPTORS; NF-KAPPA-B; PEROXISOME PROLIFERATOR; LIPID-METABOLISM; FATTY-ACIDS; ESTROGEN-RECEPTOR; FXR; EXPRESSION;

D O I：

10.3390/ijms26136345

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear receptors are proteins located in the nucleus that are involved in gene transcription and play an important role in regulating metabolism and inflammation. Systemic metabolic abnormalities and chronic inflammation in diabetic patients are associated with gene expression and activity of bile acid metabolism, lipid and carbohydrate metabolism, energy expenditure, and inflammation regulated by nuclear receptors. As a major metabolic organ, the nuclear receptor regulation signal of the liver is the key to regulating the dialog between the liver and other organs. In this review, we discuss the newly discovered role of hepatic nuclear receptor signaling in diabetes metabolism and inflammation and focus on recent advances in drug research targeting nuclear receptors in diabetes, including the use of traditional Chinese medicine.

引用

页数：30

共 148 条

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